Associations between specific types of comorbidities and physical health-related quality of life (HRQOL), self-reported hand function or hand pain and tender joint count in a hand osteoarthritis (OA) population in secondary care.
| Variables | Present, n | Mean Differences with 95% CI* | |||
|---|---|---|---|---|---|
| Physical HRQOL MCID | Self-reported Function MCII | Self-reported Pain MCII | Tender Joint Count | ||
| Self-reported comorbidity^ | |||||
| Cardiovascular disease** | 59 | −4.3 (−6.6 to −2.0) | 1.7 (−0.7. to 4.1) | 1.4 (0.2–2.7) | 1.4 (−0.1 to 2.8) |
| Pulmonary disease | 58 | −4.8 (−7.1 to −2.6) | 3.0 (0.7–5.3) | 1.2 (0.01–2.4) | 1.2 (−0.2 to 2.6) |
| Diabetes mellitus** | 40 | −2.2 (−5.0 to 0.5) | 1.8 (−1.0 to 4.6) | 1.2 (−0.2 to 2.7) | 0.9 (−0.8 to 2.5) |
| Malignant disease** | 33 | 0.3 (−2.7 to 3.2) | 0.3 (−2.7 to 3.3) | 1.2 (−0.4 to 2.7) | −0.1 (−1.9 to 1.8) |
| Gastrointestinal disease** | 24 | −2.1 (−5.5 to 1.2) | 2. (−1.1 to 5.7) | 0.9 (−0.9 to 2.7) | 0.9 (−1.2 to 3.0) |
| Osteoporosis | 42 | −1.5 (−4.2 to 1.3) | 3.6 (0.9–6.4) | 1.1 (−0.3 to 2.5) | 1.5 (−0.2 to 3.1) |
| Connective tissue disease | 48 | −4.3 (−6.7 to −1.8) | 3.6 (1.1–6.1) | 2.4 (1.1–3.7) | 2.2 (0.7–3.7) |
| Physical examination–based comorbidity^ | |||||
| Obesity | 121 | −4.1 (−5.7 to −2.4) | 1.3 (−0.4 to 3.0) | 0.8 (−0.1 to 1.7) | 0.1 (−0.9 to 1.2) |
Statistically significant data are in bold face.
↵^ All comorbidity: self-reported comorbidity; obesity: n = 519, 523.
↵* Adjusted for age and sex.
↵** Cardiovascular disease: combination of myocardial infarction, cardiac failure, peripheral vascular disease, and stroke. Diabetes mellitus: combination of diabetes with and without end-organ damage. Malignant disease: combination of malignancy and metastatic solid tumor. Gastrointestinal disease: combination of ulcer disease and mild and moderate/severe liver disease. MCID: minimal clinically important difference; MCII: minimal clinically important improvement.