Characteristics of patients with retinal toxicity.
| No. | Diagnosis | Sex/age, Yrs | Daily Dose/BW, mg/kg | Duration of Use, Yrs | Visual Field | SD-OCT | FAF | Severity |
|---|---|---|---|---|---|---|---|---|
| Pericentral pattern | ||||||||
| 1 | RA | F/54 | 8.9 | 12.8 | Partial ring scotoma | Thinning of ONL | Abnormal | Moderate |
| 2 | SLE | F/55 | 6.5 | 20.1 | Unremarkable | Disruption of IS/OS | Abnormal | Early |
| 3 | SLE | F/34 | 5.1 | 21.9 | Complete ring scotoma | Thinning of ONL | Abnormal | Moderate |
| 4 | SLE | F/52 | 8.3 | 19.5 | Defect in pattern deviation | Disruption of IS/OS | Abnormal | Moderate |
| 5 | SLE | F/56 | 9.1 | 7.3 | Partial ring scotoma | Thinning of ONL | Abnormal | Moderate |
| 6 | SLE | F/39 | 7.0 | 20.6 | Patchy pericentral ring | Thinning of ONL | Abnormal | Moderate |
| 7 | SLE | F/54 | 7.4 | 6.7 | Defect in pattern deviation | Disruption of IS/OS | Normal | Early |
| 8 | RA | F/68 | 7.0 | 15.2 | Complete ring scotoma | Thinning of ONL | Abnormal | Moderate |
| 9 | RA | F/51 | 7.1 | 13.0 | Unremarkable | Disruption of IS/OS | Abnormal | Early |
| 10 | SLE | F/40 | 4.9 | 18.1 | Defect in pattern deviation | Disruption of IS/OS | Abnormal | Moderate |
| 11 | RA | F/77 | 9.1 | 11.9 | Defect in pattern deviation | Disruption of IS/OS | Abnormal | Early |
| 12 | RA | F/57 | 5.5 | 14.8 | Defect in pattern deviation | Disruption of IS/OS | Abnormal | Moderate |
| 13 | RA | F/55 | 7.0 | 13.3 | Patchy pericentral ring | Thinning of ONL | Abnormal | Moderate |
| Mixed pattern | ||||||||
| 14 | RA | F/71 | 7.1 | 20.5 | Complete ring scotoma | Thinning of ONL | Abnormal | Severe |
| 15 | SLE | F/62 | 7.5 | 20.1 | Complete ring scotoma | Thinning of ONL | Abnormal | Severe |
| Parafoveal pattern | ||||||||
| 16 | RA | F/71 | 7.1 | 15.9 | Complete ring scotoma | Thinning of ONL | Abnormal | Severe |
| 17 | RA | M/60 | 7.0 | 7.1 | Patchy paracentral scotoma | Thinning of ONL | Abnormal | Moderate |
BW: body weight; SD-OCT: spectral domain optical coherence tomography; FAF: fundus autofluorescence; RA: rheumatoid arthritis; SLE: systemic lupus erythematosus; ONL: outer nuclear layer; IS/OS: inner segment/outer segment.