Demographics and clinical characteristics of the study population.
| Characteristics | SP-APS | SN-APS | p | ||
|---|---|---|---|---|---|
| n = 107 | % | n = 68 | % | ||
| Age, yrs, mean (SD) | 46.2 (11.1) | — | 45.8 (9.3) | — | — |
| Sex (female) | 99 | 92.5 | 67 | 98.5 | — |
| VT | 47 | 43.9 | 27 | 39.7 | — |
| DVT | 31 | 28.9 | 21 | 30.8 | — |
| PE | 30 | 28.0 | 16 | 23.5 | — |
| AT | 39 | 36.4 | 24 | 35.2 | — |
| Stroke | 18 | 16.8 | 10 | 14.7 | — |
| TIA | 16 | 14.9 | 9 | 13.2 | — |
| CAD | 4 | 3.7 | 6 | 8.8 | — |
| Thrombophilia tested | 22* | 20.6 | 24+ | 35.2 | 0.036 |
| Positive | 3/22** | 13.6 | 2/24++ | 8.3 | — |
| Pregnancy morbidity | 73/87 | 83.9 | 62/65 | 95.3 | 0.036 |
| Miscarriage | 42 | 48.2 | 44 | 67.6 | 0.021 |
| Prematurity | 20 | 22.9 | 19 | 29.2 | — |
| Preeclampsia | 24 | 27.5 | 18 | 27.6 | — |
↵* 8 VT, 1 AT, 6 VT + AT.
↵** 1 Factor V Leiden heterozygous, 1 Protein S heterozygous, 1 unknown (all 3 VT only).
↵+ 11 VT, 4 AT, 5 VT + AT.
↵++ Both Factor V Leiden heterozygous (both VT only). Pregnancy morbidity was calculated over the total number of women who have ever been pregnant (n = 87 for the SP-APS and 65 for the SN-APS groups). Only p values < 0.1 are shown and values < 0.05 are considered statistically significant. APS: antiphospholipid syndrome; SP-APS: seropositive APS; SN-APS: seronegative APS; VT: venous thrombosis; AT: arterial thrombosis; DVT: deep vein thrombosis; PE: pulmonary embolism; TIA: transient ischemic attack; CAD: carotid artery disease.