Comparison between patients with ANCA-associated vasculitis with and without severe infection. Results are given as mean (± SD) for normally distributed variables and median (IQR) for not normally distributed variables.
| Characteristics | Severe Infection, n = 86 | No Severe Infection, n = 100 | p |
|---|---|---|---|
| Age at diagnosis, yrs, mean ± SD | 68.8 ± 13.5 | 60.8 ± 16.8 | < 0.001 |
| Sex, F:M | 41:45 | 54:46 | 0.4 |
| Diagnosis: GPA/MPA/EGPA | 47/36/3 | 45/47/8 | |
| PR3 + ANCA: MPO + ANCA, n = 92: n = 78 | 41:38 | 51:40 | 0.5 |
| Laboratory data at diagnosis | |||
| Serum creatinine, μmol/l | 238 (75–350) | 117 (73–256) | 0.01 |
| Hemoglobin concentration, g/l | 106 ± 20 | 113 ± 18 | 0.03 |
| White blood cell count | 11 (9–14) | 11 (8–14) | 0.9 |
| Platelet count | 370 ± 133 | 391 ± 136 | 0.2 |
| C-reactive protein, mg/l | 101 ± 86 | 92 ± 77 | 0.4 |
| ESR, mm/h | 66 ± 34 | 67 ± 33 | 0.9 |
| *Patients with GFR < 50 ml/min/1.73 m2 | 52/75 (69%) | 47/89 (53%) | 0.03 |
| Deaths | 40 (46.5%) | 26 (26%) | 0.004 |
| ESRD | 22 (25.6%) | 10 (10%) | 0.002 |
↵* At diagnosis. ANCA: antineutrophil cytoplasmic antibody; IQR: interquartile range; ESR: erythrocyte sedimentation rate; GPA: granulomatosis with polyangiitis; MPA: microscopic polyangiitis; EGPA: eosinophilic granulomatosis with polyangiitis; PR3: proteinase 3; MPO: myeloperoxidase; GFR: glomerular filtration rate; ESRD: endstage renal disease.