Alternate definitions used to classify patients based on adherence to anti-TNF recommendations.
| Disease Activity Pre-index | No Anti-TNF Use | Anti-TNF Use |
|---|---|---|
| Main analysis | ||
| 0 visits, ≥ 1 nonconsecutive visits, or ≤ 2 consecutive visits | Adherent nonuser (no anti-TNF need) | Adherent user (timely anti-TNF use) |
| BASDAI and PGA ≥ 4 > 2 consecutive visits BASDAI and PGA ≥ 4 | Nonadherent nonuser (unmet anti-TNF need) | Nonadherent user (late anti-TNF use) |
| Sensitivity analysis | ||
| 0 or ≥ 1 nonconsecutive visits BASDAI and PGA ≥ 4 | Adherent nonuser (no anti-TNF need) | Adherent user (timely anti-TNF use) |
| ≥ 2 consecutive visits BASDAI and PGA ≥ 4 | Nonadherent nonuser (unmet anti-TNF need) | Nonadherent user (late anti-TNF use) |
Anti-TNF: antitumor necrosis factor; BASDAI: Bath Ankylosing Spondylitis Disease Activity Index; PGA: physician’s global assessment.