Characteristics | HR | 95% CI | p |
---|---|---|---|
Univariate analysis | |||
Anti-ARS antibody–positive | 0.57 | 0.29–0.96 | 0.035* |
Anti-MDA5 antibody–positive | 1.80 | 1.08–2.92 | 0.025* |
Female | 0.67 | 0.41–1.09 | 0.11 |
Age, yrs | 1.04 | 0.99–1.09 | 0.09 |
Smoking, current/former, vs never | 1.15 | 0.70–1.86 | 0.57 |
ILD onset, acute/subacute, vs chronic | 2.11 | 1.24–3.99 | < 0.01* |
Myositis diagnosis, CADM/DM, vs PM | 0.81 | 0.46–1.70 | 0.53 |
PaO2, per 10 Torr increase | 0.49 | 0.33–0.74 | < 0.001* |
%FVC, per 10% increase | 0.62 | 0.42–0.87 | < 0.01* |
FEV1.0/FVC, per 10% increase | 0.55 | 0.25–1.17 0.12 | |
KL-6, per 100 U/ml increase | 1.01 | 0.95–1.05 | 0.71 |
SP-D, per 10 ng/ml increase | 0.99 | 0.95–1.02 | 0.54 |
CPK, per 100 U/ml increase | 1.004 | 0.96–1.03 | 0.84 |
Ferritin, per 100 ng/ml increase | 1.03 | 1.01–1.04 | < 0.01 * |
YKL-40, per 10 ng/ml increase | 1.15 | 1.07–1.24 | < 0.001* |
Multivariate analysis | |||
Adjusted for anti-ARS antibody status | |||
PaO2, per 10 Torr increase | 0.62 | 0.32–1.18 | 0.15 |
%FVC, per 10% increase | 0.64 | 0.42–0.90 | < 0.01* |
Ferritin, per 100 ng/ml increase | 1.02 | 0.99–1.04 | 0.15 |
YKL-40, per 10 ng/ml increase | 1.15 | 1.04–1.28 | < 0.01* |
Adjusted for anti-MDA5 antibody status | |||
PaO2, per 10 Torr increase | 0.61 | 0.31–1.16 | 0.13 |
%FVC, per 10% increase | 0.65 | 0.42–0.93 | 0.01* |
Ferritin, per 100 ng/ml increase | 1.02 | 0.99–1.04 | 0.20 |
YKL-40, per 10 ng/ml increase | 1.15 | 1.04–1.29 | < 0.01* |
↵* p < 0.05. ARS: antiaminoacyl tRNA-synthetase antibody; MDA5: antimelanoma differentiation-associated gene 5 antibody; ILD: interstitial lung disease; CADM: clinically amyopathic dermatomyositis; DM: dermatomyositis; PM: polymyositis; PaO2: arterial oxygen pressure; Torr: a unit of pressure based on an absolute scale, defined as exactly 1/760 of a standard atmosphere; %FVC: predicted forced vital capacity; FEV1.0: forced expiratory volume 1.0 s; KL-6: Krebs von den Lungen-6; SP-D: surfactant protein-D; CPK: creatine phosphokinase; YKL: chitinase-3-like-1 protein.