Table 2.

Mixed-models analysis of changes in CVD-related factors over 5 years. Values are mean ± SD or median (interquartile range) unless otherwise specified.

Variable	Mean	β	95% CI	p
Systolic blood pressure	130 ± 20	−0.001	−0.02 to 0.02	0.92
Diastolic blood pressure	81 ± 11	0.002	−0.01 to 0.01	0.66
BMI	27 ± 5	0.002	−0.0001 to 0.004	0.07
Creatinine	75 ± 17	−0.003	−0.01 to 0.01	0.55
TC	5.38 ± 1.12	0.0008	0.0001–0.001	0.03
Adjusted^*		0.0008	−0.0001 to 0.002	0.02
HDLc	1.34 ± 0.45	0.0005	0.0001–0.001	< 0.01
Adjusted^*		0.0005	0.0002–0.001	< 0.01
LDLc	3.19 ± 0.98	0.0008	−0.0001 to 0.002	0.03
Adjusted^*		0.0009	−0.0001 to 0.002	0.02
Triglycerides	1.37 (0.96–2.00)	−0.00003	−0.0005 to 0.0005	0.99
TC/HDLc ratio	4.01 ± 1.30	0.0006	−0.0006 to 0.002	0.31
ApoA-I^{^}	1.59 ± 0.34	0.00001	−0.0005 to 0.0005	0.98
ApoB^{^}	0.89 ± 0.24	−0.0001	−0.0004 to 0.0001	0.34
ApoB/apoA-I ratio^{^}	0.58 ± 0.20	−0.0002	−0.0005 to 0.00001	0.06
Adjusted^*		−0.0003	−0.0005 to −0.00005	0.02

↵* Adjusted for age, sex, disease duration, concomitant methotrexate, prednisone, and statin use.
↵^ Subanalysis of 81 patients at baseline with apoA-I and apoB measurements available. CVD: cardiovascular disease; BMI: body mass index; TC: total cholesterol; HDLc: high-density lipoprotein cholesterol; LDLc: low-density lipoprotein cholesterol; apoA-I: apolipoprotein A-I; apoB: apolipoprotein B.