Demographics and clinical information of the patients at the time of urine collection and the time of kidney biopsy. Values are arithmetic means (SD), unless stated otherwise.
| Variable | Category | Total, n = 87 | Responders, n = 37 | Nonresponders, n = 50 | p## |
|---|---|---|---|---|---|
| Sex, n (%) | Female | 68 (78.2) | 27 (73.0) | 41 (82.0) | 0.314 |
| Race/ethnicity, n (%) | White | 29 (33.3%) | 19 (51.4) | 10 (20.0) | 0.015 |
| Black | 33 (38.0) | 12 (32.4) | 21 (42.0) | ||
| Hispanic | 10 (11.5) | 2 (5.4) | 8 (16.0) | ||
| Mixed racial and others | 15 (17.2) | 4 (10.8) | 11 (22.0) | ||
| Medications started for LN therapy around kidney biopsy, n (%) | Mycophenolate mofetil | 47 (54.0) | 17 (46.0) | 30 (60.0) | 0.194 |
| Azathioprine | 7 (8.1) | 5 (13.5) | 2 (4.0) | ||
| Cyclophosphamide | 33 (37.9) | 15 (40.5) | 18 (36.0) | ||
| Angiotensin system–blocking drug, n (%) | Yes | 51/87 (58.6) | 20 (54) | 31 (62) | 0.202 |
| GFR, ml/min/m2 | 135.6 (57.4) | 141.0 (66.4) | 131.6 (50.1) | 0.459 | |
| Renal SLEDAI | 8.0 (5.2) | 5.4 (4.7) | 9.8 (4.7) | < 0.0001 | |
| Renal BILAG | 9.9 (4.0) | 8.2 (5.1) | 11.2 (2.1) | 0.0003 | |
| Microalbumin/creatinine ratio** | 1.16 (2.04) | 0.80 (2.23) | 1.54 (1.83) | 0.122 | |
| ISN/RPS, n (%) # | Class 2 | 13 (14.9) | 5 (13.5) | 8 (16.0) | 0.634 |
| Class 3 or 4 | 47 (54.0) | 22 (59.5) | 25 (50.0) | ||
| Class 5 | 27 (31.0) | 10 (27.0) | 17 (34.0) | ||
| NIH-AI ‡ | 7.6 (6.5) | 7.7 (6.0) | 7.5 (6.9) | 0.917 | |
| NIH-CI Δ | 1.6 (1.9) | 1.6 (1.4) | 1.6 (2.1) | 0.952 | |
| Extrarenal SLEDAI* | 6.7 (6.8) | 3.8 (3.3) | 8.8 (8.0) | 0.004 |
↵## P values are from t tests to compare means or chi square tests to compare rates (in %).
↵# International Society for Nephrology/Renal Pathology Society Class; there were no biopsies consistent with Class 1 or 6.
↵‡ US National Institutes of Health (NIH) Activity Index; range 0–24; 0 = inactive LN; available in only 76 patients.
↵Δ NIH Chronicity Index; range 0–12; 0 = LN without chronic changes; available in only 62 patients.
↵* Measured by the SLEDAI summary score minus the SLEDAI renal domain score.
↵** Natural log transformed. GFR: glomerular filtration rate; LN: lupus nephritis; SLEDAI: Systemic Lupus Disease Activity Index; BILAG: British Isles Lupus Activity Group.