Characteristics of SS and comparison cohorts at baseline. Values are n (%) unless otherwise specified.
| Variable | SS, n = 1175 | Non-SS, n = 11,947 | p |
|---|---|---|---|
| Age, yrs, mean (SD) | 56.73 (15.27) | 56.67 (15.2) | 0.902 |
| Female | 1029 (87.6) | 10441 (87.4) | 0.890 |
| Alcoholism with liver disease | 10 (0.9) | 86 (0.7) | 0.589 |
| Hypertension | 303 (25.8) | 2778 (23.3) | 0.052 |
| Sepsis | 13 (1.1) | 18 (0.2) | < 0.001 |
| Varicose veins | 27 (2.3) | 121 (1) | < 0.001 |
| Inflammatory bowel disease | 4 (0.3) | 32 (0.3) | 0.560 |
| Trauma | 1 (0.1) | 25 (0.2) | 0.726 |
| Fractures | 28 (2.4) | 166 (1.4) | 0.011 |
| Surgery | 13 (1.1) | 84 (0.7) | 0.149 |
| Charlson Comorbidity Index, mean (SD) | 1.06 (1.54) | 0.36 (1.07) | < 0.001 |
| Glucocorticoids | 239 (20.3) | 510 (4.3) | < 0.001 |
| Hormone replacement therapy | 139 (11.8) | 823 (6.9) | < 0.001 |
| Oral contraceptives | 44 (3.7) | 439 (3.7) | 0.871 |
| COX-2 inhibitors | 94 (8) | 356 (3) | < 0.001 |
| Hospitalized | 364 (31) | 1898 (15.9) | < 0.001 |
| No. outpatient visits, mean (SD) | 20.68 (17.95) | 9.09 (10.85) | < 0.001 |
SS: Sjögren syndrome; COX: cyclooxygenase.