Study | Outcome(s) Assessed | OA/non-OA | Variables Adjusted For | Results (95% CI or p value) | Conclusion |
---|---|---|---|---|---|
Fat mass | |||||
Patellar cartilage defects | |||||
Cross-sectional studies: association between fat mass and patellar cartilage defects | |||||
Teichtahl, et al27 | Presence of patellar cartilage defects | Non-OA | Age, patellar cartilage volume, and fat-free mass | Men, increased odds of defects, OR 1.11 (95% CI 1.01–1.23), p = 0.04; women, no increased odds of defects, OR 1.06 (95% CI 0.99–1.13), p = 0.09 | Higher fat mass was significantly associated with patellar cartilage defects for men only |
Longitudinal studies: association between change in fat mass over previous period and patellar cartilage defects | |||||
Teichtahl, et al27 | Presence of patellar cartilage defects | Non-OA | Age, patellar cartilage volume, and fat-free mass | Men, no increased odds of defects, OR 1.03 (95% CI 0.89–1.18), p = 0.71; women, no increased odds of defects, OR 1.10 (95% CI 0.99–1.21), p = 0.08 | No significant association between change in fat mass over the previous 10 yrs and patellar cartilage defects |
Patellar cartilage volume | |||||
Cross-sectional studies: association between fat mass and patellar cartilage volume | |||||
Teichtahl, et al27 | Patellar cartilage volume | Non-OA | Age and fat-free mass | Men, patellar cartilage volume, regression coefficient: −14.8 (95% CI −50.2 to 20.7), p = 0.41; women, patellar cartilage volume, regression coefficient: 2.2 (95% CI −15.4 to 19.8), p = 0.80 | No significant association between fat mass and patellar cartilage volume |
Longitudinal studies: association between change in fat mass over previous period and current patellar cartilage volume | |||||
Teichtahl, et al27 | Patellar cartilage volume | Non-OA | Age and fat-free mass | Men, relationship between change in fat mass and current patellar cartilage volume, regression coefficient: −15.3 (95% CI −50.9 to 20.3), p = 0.40; women, relationship between change in fat mass and current patellar cartilage volume, regression coefficient: 2.3 (95% CI −15.7 to 20.3), p = 0.80 | No significant association between change in fat mass over the previous 10 yrs and patellar cartilage volume |
Longitudinal studies: association between baseline fat mass and change in patellar cartilage volume | |||||
Teichtahl, et al35 | Annual change in patellar cartilage volume | Non-OA | Age, gender, baseline patella bone, and participation in physical activity | Men, association with annual loss of patellar cartilage volume, regression coefficient: 1.8 (95% CI −0.8 to 4.4), p = 0.17; women, association with annual loss of patellar cartilage volume, regression coefficient: 1.8 (95% CI 0.2–3.4), p = 0.03 | Higher fat mass was significantly associated with increased loss of patellar cartilage volume for women only |
Longitudinal studies: association between change in fat mass and change in patellar cartilage volume | |||||
Teichtahl, et al35 | Annual change in patellar cartilage volume | Non-OA | Age, baseline patella bone and cartilage volume, and physical activity | Data not shown | No significant association between change in fat mass and change in knee cartilage |
Fat-free mass | |||||
Patellar cartilage defects | |||||
Cross-sectional studies: association between fat-free mass and patellar cartilage defects | |||||
Teichtahl, et al27 | Presence of patellar cartilage defects | Non-OA | Age, patellar cartilage volume, and fat mass | Men, increased odds of defects, OR 1.07 (95% CI 0.94–1.21), p = 0.34; significantly women, increased odds of defects, OR 1.19 (95% CI 1.03–1.38), p = 0.02 | Higher fat-free mass was associated with patellar cartilage defects for women only |
Longitudinal studies: association between change in fat-free mass over previous period and patellar cartilage defects | |||||
Teichtahl, et al27 | Presence of patellar cartilage defects | Non-OA | Age, patellar cartilage volume, and fat mass | Men, increased odds of defects, OR 1.21 (95% CI 1.01–1.45), p = 0.04; women, increased odds of defects OR 1.34 (95% CI 1.11–1.63), p = 0.003 | Greater increase in fat-free mass was significantly associated with patellar cartilage defects |
Patellar cartilage volume | |||||
Cross-sectional studies: association between fat-free mass and patellar cartilage volume | |||||
Teichtahl, et al27 | Patellar cartilage volume | Non-OA | Age, fat mass | Men, patellar cartilage volume, regression coefficient: 16.5 (95% CI −32.2 to 65.3), p = 0.50; women, patellar cartilage volume, regression coefficient: 0.1 (95% CI −40.2 to 40.3), p = 0.99 | No significant association between fat-free mass and patellar cartilage volume |
Longitudinal studies: association between change in fat-free mass over previous period and current patellar cartilage volume | |||||
Teichtahl, et al27 | Patellar cartilage volume | Non-OA | Age, fat mass | Men, relationship between change in fat-free mass and current patellar cartilage volume, regression coefficient: 17.4 (95% CI −31.5 to 66.3), p = 0.48; women, relationship between change in fat-free mass and current patellar cartilage volume, regression coefficient: −1.0 (95% CI −42.1 to 40.2), p = 0.96 | No significant association between fat-free mass and patellar cartilage volume |
OA: osteoarthritis.