Clinical characteristics of patients. All values are presented as n (percent) or mean ± SD.
| Characteristics | Active AOSD, n = 40 | Inactive AOSD, n = 16 | RA, n = 28 | HC, n = 27 |
|---|---|---|---|---|
| Age, yrs | 42.5 ± 17.2 | 38.9 ± 15.6 | 48 ± 9.5 | 42.8 ± 10.5 |
| Sex, F/M | 34/6 | 12/4 | 24/4 | 24/3 |
| Symptom duration or disease duration, mos | 1.0 ± 0.6 | 8.6 ± 8.3 | 41.4 ± 27.7 | |
| Fever | 38 (95) | 0 (0) | ||
| Sore throat | 21 (52.5) | 0 (0) | ||
| Rash | 34 (85) | 1 (6.3) | ||
| Lymphadenopathy | 14 (35) | 0 (0) | ||
| Splenomegaly | 8 (20) | 0 (0) | ||
| Hepatomegaly | 7 (17.5) | 0 (0) | ||
| Pericarditis | 6 (15) | 0 (0) | ||
| Pleuritis | 5 (12.5) | 0 (0) | ||
| Arthralgia | 36 (90) | 2 (12.5) | ||
| Arthritis | 20 (50) | 1 (6.3) | ||
| Hemoglobin, g/dl | 11.2 ± 1.7 | 12.7 ± 1.7 | 12.9 ± 1.4 | |
| Leukocyte, /μl | 13,689 ± 4920 | 8256 ± 1660 | 7692.9 ± 3437 | |
| Platelet, ×103/μl | 307.3 ± 113.2 | 258.3 ± 57.2 | 253.8 ± 61.6 | |
| Ferritin, ng/ml | 6775.4 ± 10,307.6 | 159.8 ± 206.1 | ||
| ESR, mm/h | 57.8 ± 21.5 | 10.0 ± 8.7 | 28.5 ± 17.0 | |
| CRP, mg/dl | 8.76 ± 6.34 | 0.17 ± 0.19 | 0.93 ± 2.26 | |
| AST, mg/dl | 77.8 ± 64.3 | 23.9 ± 7.8 | 24.8 ± 10.6 | |
| ALT, mg/dl | 79.3 ± 92.2 | 23.1 ± 12.2 | 23.5 ± 18.0 | |
| Bilirubin, mg/dl | 0.70 ± 0.77 | 0.76 ± 0.33 | 0.58 ± 0.21 | |
| Albumin, g/dl | 3.70 ± 0.65 | 4.46 ± 0.22 | 4.44 ± 0.29 | |
| ANA positivity | 4 (10) | 7 (25) | ||
| RF positivity | 1 (2.5) | 26 (75) | ||
| Systemic score | 5.37 ± 1.30 | 0.19 ± 0.40 | ||
| DAS28 | 3.87 ± 1.13 | |||
| Methotrexate | 12 (75.0) | 18 (64.3) | ||
| Cyclosporine | 2 (12.5) | 0 (0) | ||
| Leflunomide | 0 (0) | 5 (17.8) | ||
| Hydroxychloroquine | 5 (31.3) | 22 (78.6) | ||
| Daily corticosteroid (mg prednisolone equivalent) | 5.86 ± 3.11 | 2.28 ± 1.87 |
The systemic scoring system of Pouchot, et al21 assigns a score from 0 to 12 with 1 point for each of the following manifestations: fever, typical rash, pleuritis, pneumonia, pericarditis, hepatomegaly or abnormal liver function test data, splenomegaly, lymphadenopathy, leukocytosis ≥ 15,000/mm2, sore throat, myalgia, and abdominal pain. AOSD: adult-onset Still’s disease; RA: rheumatoid arthritis; HC: healthy controls; LDH: lactate dehydrogenase; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; AST: aspartate transaminase; ALT: alanine transaminase; ANA: antinuclear antibody; RF: rheumatoid factor; DAS28: 28-joint Disease Activity Score.