Table 3.

Interleukin 33 (IL-33) and ST2 immunohistochemical stain results in skin biopsies of 34 patients with adult-onset Still’s disease (AOSD), 5 healthy controls (HC), 5 eczema samples, and 5 psoriasis samples.

	Grade	AOSD	HC	p (AOSD vs HC)	Eczema	p (AOSD vs eczema)	Psoriasis	p (AOSD vs psoriasis)
Positive inflammatory cells for IL-33	0	14 (41.2)	5 (100)	0.02	1 (20)	0.631	3 (60)	0.636
	1	20 (58.8)	0 (0)		4 (80)		2 (40)
	2	0 (0)	0 (0)		0 (0)		0 (0)
	3	0 (0)	0 (0)		0 (0)		0 (0)
Positive endothelial cells for IL-33	0	0 (0)	0 (0)	0.006	0 (0)	0.056	0 (0)	0.239
	1	8 (23.5)	0 (0)		0 (0)		0 (0)
	2	17 (50)	5 (100)		1 (20)		2 (40)
	3	9 (26.5)	0 (0)		4 (80)		3 (60)
Positive keratinocytes for IL-33	0	21 (61.8)	0 (0)	0.01	2 (40)	0.649	1 (20)	0.205
	1	9 (26.5)	1 (20)		2 (40)		3 (60)
	2	4 (11.8)	3 (60)		1 (20)		1 (20)
	3	0 (0)	1 (20)		0 (0)		0 (0)
Positive inflammatory cells for ST2	0	1 (2.9)	5 (100)	< 0.001	0 (0)	0.017	0 (0)	0.118
	1	10 (29.4)	0 (0)		0 (0)		0 (0)
	2	14 (41.2)	0 (0)		0 (0)		1 (20)
	3	9 (26.5)	0 (0)		5 (100)		4 (80)
Positive endothelial cells for ST2	0	2 (5.9)	0 (0)	0.265	0 (0)	0.009	0 (0)	0.009
	1	11 (32.4)	0 (0)		0 (0)		0 (0)
	2	13 (38.2)	2 (40)		0 (0)		0 (0)
	3	8 (23.5)	3 (60)		5 (100)		5 (100)
Positive keratinocytes for ST2	0	14 (41.2)	2 (40)	0.235	0 (0)	0.133	0 (0)	0.36
	1	12 (35.3)	0 (0)		3 (60)		3 (60)
	2	4 (11.8)	1 (20)		2 (40)		1 (20)
	3	4 (11.8)	2 (40)		0 (0)		1 (20)

These results used a Mann-Whitney U test.