Demographic and clinical characteristics of the patients among 4 histological classes.
| Characteristics | Histopathological Classes | p* | |||
|---|---|---|---|---|---|
| Focal, n = 46 | Crescentic, n = 36 | Sclerotic, n = 36 | Mixed, n = 68 | ||
| Male/female, n | 19/27 | 17/19 | 14/22 | 31/37 | 0.87 |
| Age, yrs, mean ± SD | 53.9 ± 17.7 | 56.3 ± 14.8 | 58.2 ± 13.7 | 58.2 ± 12.7 | 0.43 |
| MPO-ANCA/PR3-ANCA, n | 33/13 | 32/4 | 33/3 | 65/3 | 0.002 |
| Extrarenal involvement, n (%) | |||||
| Lung and upper respiratory tract | 27 (58.7) | 31 (86.1) | 25 (69.4) | 48 (70.6) | 0.06 |
| ENT | 16 (34.8) | 18 (50) | 17 (47.2) | 19 (27.9) | 0.08 |
| Nervous system | 7 (15.2) | 8 (22.2) | 5 (13.9) | 6 (8.8) | 0.31 |
| Cutaneous/mucous membranes/eyes | 8 (17.4) | 4 (11.1) | 3 (8.3) | 5 (7.4) | 0.42 |
| BVAS, median | 19 | 25 | 18 | 18 | < 0.001 |
↵* p value applies to the variable across the differing histological classes. ANCA: antineutrophil cytoplasmic antibodies; MPO-ANCA: myeloperoxidase ANCA; PR3-ANCA: proteinase 3 ANCA; BVAS: Birmingham Vasculitis Activity Score.