Case series and reports looking at combination therapies.
| Intervention | No. Case Series/Reports | Total No. Patients | Positive Outcomes | Negative Outcomes | Objective Measure of Outcome? |
|---|---|---|---|---|---|
| Rasburicase and allopurinol62 | 1 | 1 | Reduction in tophi; SUA reduction | Flare after each infusion | Size |
| Benzbromarone and allopurinol63 | 1 | 1 | Resolution of tophi; improved function | None | Pictoral |
| Anakinra and hemodialysis64 | 1 | 1 | Resolution of tophi; improved function | None | Pictoral |
| Benzbromarone + allopurinol, arthroscopic removal65 | 1 | 1 | Improved function | None | None |
| Debridement, vacuum assisted dressing, and allopurinol66 | 1 | 1 | No recurrence of tophi | None | None |
| Excision/ debridement/ joint replacement and allopurinol67,68,69,70,71,72,73,74 | 8 | 8 | Reduction in pain; improved function | Postoperative ischemic ulceration (1); recurrence of tophi (1) | None |
SUA: Serum uric acid.