Arthritis development following TnfΔARE bone marrow reconstitution of lethally irradiated recipients. From Armaka, et al, J Exp Med 2008;205:331–7; with permission43.
Donor Genotype
Recipient Genotype
Arthritis Development
WT
WT
0/20
TnfΔARE/+
WT
19/21
TnfΔARE/ΔARE TnfRI−/−
WT
25/25
TnfΔARE/+
TnfRI−/−
0/8
ARE: adenosine- and uridine-rich elements; WT: wild-type.