Table 3.

Effects of hypoxia on synovial cell cytokine release. Tenosynovial tissue was enzymatically dissociated and cells were cultured in either 1% oxygen (hypoxia) or 21% oxygen (normoxia) for a period of 24 hours. Cytokine and receptor release (ng/ml) into supernatants was measured by ELISA. Data are shown as median (interquartile range) and were analyzed by paired t test (for Gaussian distribution: IL-10, soluble VEGF-R1, VEGF) or Wilcoxon signed-rank test (for nonparametric data: IL-6, IL-8, MCP-1) versus normoxia. Sivakumar B, et al, J Hand Surg Am 2008;33:49–58125; with permission from Elsevier.

IL-68.64 (6.03–37.45)7.92 (5.06–38.46)120.677
IL-83.11 (1.85–6.37)3.09 (1.92–7.61)120.622
MCP-15.37 (2.06–31.80)2.25 (0.80–9.41)130.0002
IL-102.86 (1.86–4.76)1.76 (0.86–2.99)120.001
VEGF1.97 (0.79–3.92)4.86 (1.798–7.02)110.004
Soluble VEGF-R10.16 (0.10–0.29)0.27 (0.15–0.43)140.001
  • IL-6: interleukin 6; MCP-1: monocyte chemoattractant protein-1; VEGH: vascular endothelial growth factor; VEGF-R1: vascular endothelial growth factor receptor 1.