Table 1.

Strength of association between immune mediated-inflammatory diseases and HLA. From Zhernakova A, et al, Nat Rev Genet 2009; 10:43–554; adapted with permission from Macmillan Publishers Ltd.

DiseaseAssociation* to HLA**PAR
Ankylosing spondylitisStrong0.43
Crohn’s diseaseWeak0.03
Rheumatoid arthritisStrong0.5
Ulcerative colitisWeak-moderate0.16
  • * Only human leukocyte antigen (HLA) association in Caucasians has been reported.

  • ** HLA association: strong if the odds ratio for reported alleles is above 4; moderate if the odds ratio is between 2 and 4; and weak if the odds ratio is below 2.

  • Population attributable risk (PAR) was calculated based on the HLA single-nucleotide polymorphisms that showed the strongest association to the disease in genome-wide association studies.