Strength of association between immune mediated-inflammatory diseases and HLA. From Zhernakova A, et al, Nat Rev Genet 2009; 10:43–554; adapted with permission from Macmillan Publishers Ltd.
| Disease | Association* to HLA** | PAR† |
|---|---|---|
| Ankylosing spondylitis | Strong | 0.43 |
| Crohn’s disease | Weak | 0.03 |
| Psoriasis | Moderate-strong | 0.21 |
| Rheumatoid arthritis | Strong | 0.5 |
| Ulcerative colitis | Weak-moderate | 0.16 |
↵* Only human leukocyte antigen (HLA) association in Caucasians has been reported.
↵** HLA association: strong if the odds ratio for reported alleles is above 4; moderate if the odds ratio is between 2 and 4; and weak if the odds ratio is below 2.
↵† Population attributable risk (PAR) was calculated based on the HLA single-nucleotide polymorphisms that showed the strongest association to the disease in genome-wide association studies.