Validation.
| Disease | Questions | Sensitivity (95% CI) | Specificity (95% CI) | κ (95% CI) |
|---|---|---|---|---|
| Sample population | — | 0.91 (0.88–0.94) | 0.99 (0.96–1.00) | 0.82 (0.77–0.88) |
| SLE | Screening | 1.00 (0.89–1.00) | 0.95 (0.89–0.98) | 0.88 (0.79–0.97) |
| Confirmatory | 0.73 (0.56–0.86) | 0.98 (0.94–0.99) | 0.77 (0.64–0.91) | |
| RA | Screening | 1.00 (0.72–1.00) | 0.88 (0.82–0.93) | 0.52 (0.32–0.72) |
| Confirmatory | 0.60 (0.31–0.83) | 0.98 (0.93–0.99) | 0.61 (0.34–0.87) | |
| SSc | Screening | 1.00 (0.86–1.00) | 1.00 (0.97–1.00) | 1.00 (1.00–1.00) |
| Confirmatory 1 | 0.71 (0.51–0.85) | 1.00 (0.97–1.00) | 0.80 (0.66–0.94) | |
| Confirmatory 2 | 0.92 (0.74–0.98) | 1.00 (0.97–1.00) | 0.95 (0.88–1.00) | |
| PM or DM* | Screening | 1.00 (0.65–1.00) | 0.96 (0.92–0.98) | 0.72 (0.49–0.95) |
| Confirmatory 1 | 1.00 (0.65–1.00) | 0.96 (0.92–0.98) | 0.72 (0.49–0.95) | |
| Confirmatory 2 | 0.71 (0.36–0.92) | 0.97 (0.93–0.99) | 0.60 (0.31–0.89) | |
| Sjögren syndrome | Screening | 1.00 (0.77–1.00) | 0.97 (0.92–0.99) | 0.85 (0.71–0.99) |
| Confirmatory 1 | 0.92 (0.67–0.99) | 0.98 (0.94–1.00) | 0.88 (0.74–1.00) | |
| Confirmatory 2 | 0.61 (0.36–0.82) | 0.99 (0.96–1.00) | 0.71 (0.48–0.93) | |
| APS* | Screening | 1.00 (0.44–1.00) | 1.00 (0.97–1.00) | 1.00 (1.00–1.00) |
| Confirmatory | 1.00 (0.44–1.00) | 1.00 (0.97–1.00) | 1.00 (1.00–1.00) | |
| Hemolytic anemia* | Screening | 0.33 (0.06–0.79) | 0.98 (0.95–0.99) | 0.32 (−0.18 to 0.81) |
| Confirmatory | 0.33 (0.06–0.79) | 1.00 (0.97–1.00) | 0.50 (−0.11 to 1.00) | |
| Multiple sclerosis* | Screening | 1.00 | 0.99 (0.96–0.99) | 0.89 (0.66–1.00) |
| Confirmatory | 1.00 (0.51–1.00) | 0.99 (0.96–1.00) | 0.89 (0.66–1.00) | |
| Thyroid | Screening | 0.96 (0.80–0.99) | 0.98 (0.94–1.00) | 0.93 (0.85–1.00) |
| Confirmatory | 0.88 (0.72–0.96) | 0.98 (0.94–1.00) | 0.88 (0.77–0.98) | |
| Type 1 diabetes mellitus* | Screening | 1.00 (0.61–1.00) | 0.99 (0.96–1.00) | 0.92 (0.76–1.00) |
| Confirmatory | 0.00 (0.00–0.39) | 0.99 (0.96–1.00) | −0.01 (−0.03 to 0.01) |
↵* Indicates diseases with n < 10. Screening: screening question; confirmatory 1: first confirmatory question; confirmatory 2: second confirmatory question. SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; SSc: systemic sclerosis; DM: dermatomyositis; PM: polymyositis; APS: antiphospholipid antibody syndrome.