SSc criteria sets definition.
| ACR 198011 | Leroy and Medsger 200112 | ACR/EULAR 201314 | |
|---|---|---|---|
| Major criteria: Scleroderma proximal to MCP/MTP joints Minor criteria: Sclerodactyly, digital ulcers, bibasilar pulmonary fibrosis on chest radiograph | Presence of RP and (1) SSc-type nailfold capillary pattern and/or (2) SSc-related antibodies (ACA, anti Scl-70, anti-PM-Scl, anti-fibrillin, anti-RNA polymerase III, anti-Th/To) | Items | Score |
| Bilateral skin thickening proximal to the MCP joints | 9 | ||
| Skin thickening of whole finger distal to MCP or puffy fingers | 4 or 2 | ||
| Fingertip lesions: digital ulcers or pitting scars | 2 or 3 | ||
| Telangiectasia | 2 | ||
| Abnormal nailfold capillaries | 2 | ||
| Pulmonary arterial hypertension or interstitial lung disease | 2 | ||
| RP | 3 | ||
| SSc-related antibodies (ACA, anti Scl-70, anti RNA polymerase III) | 3 | ||
| Requires 1 major or 2 minor criteria | Requires either (1) or (2) if RP is objectively documented. Requires (1) and (2) if RP is subjective | Requires a total score of 9 or more |
ACR: American College of Rheumatology; EULAR: European League Against Rheumatism; SSc: systemic sclerosis; RP: Raynaud phenomenon; ACA: anticentromere antibodies; MCP: metacarpophalangeal; MTP: metatarsophalangeal.