Biological drugs approved for treating PsA.
| Biological DMARD | Target | Structure |
|---|---|---|
| Etanercept | TNF-α | Human TNF-α receptor p75Fc fusion protein |
| Infliximab | TNF-α | Chimeric human-murine anti-TNF-α mAb |
| Adalimumab | TNF-α | Recombinant human anti-TNF-α mAb |
| Certolizumab | TNF-α | Fab’ pegylated anti-TNF-α |
| Golimumab | TNF-α | mAb anti-TNF-α |
| Ustekinumab | IL-12/IL-23 | mAb that blocks p40 |
PsA: psoriatic arthritis; DMARD: disease-modifying antirheumatic drugs; TNF: tumor necrosis factor-α; mAb: monoclonal antibody; IL: interleukin.