Variable estimates from the generalized linear mixed effect model analysis of the effect of radiographic spinal progression (mSASSS) and disease activity change (BASDAI) on the change in the functional status (BASFI) and spinal mobility (BASMI) during longterm treatment with TNF inhibitors.
| Independent Variables | Outcome (Dependent Variable) | |||
|---|---|---|---|---|
| BASFI Change from Baseline (Week 12) | BASMI Change from Baseline (Week 12) | |||
| β (95% CI) | p | β (95% CI) | p | |
| mSASSS change from baseline | 0.0 (−0.03 to 0.03) | 0.89 | 0.05 (0.01–0.09) | 0.022 |
| BASDAI change from baseline (Week 12) | 0.64 (0.54–0.73) | < 0.001 | 0.14 (0.01–0.26) | 0.035 |
mSASSS: modified Stoke Ankylosing Spondylitis Spine Score; BASDAI: Bath Ankylosing Spondylitis Disease Activity Index; BASFI: Bath Ankylosing Spondylitis Functional Index; BASMI: Bath Ankylosing Spondylitis Metrology Index; TNF: tumor necrosis factor.