Reasons to Discontinue TNFi | Monotherapy 181/320 | SSZ 48/103 | LEF 46/80 | Other csDMARD 42/99 | MTX Alone 347/919 | MTX+ csDMARD 159/412 |
---|---|---|---|---|---|---|
Side effects | 42.9 | 51.4 | 54.5 | 48.8 | 43.4 | 45.6 |
Ineffectiveness | 50.6 | 48.6 | 43.2 | 46.3 | 50.6 | 52.4 |
Ineffectiveness and side effects | 6.5 | 0.0 | 2.3 | 4.9 | 6.0 | 2.0 |
TNFi: tumor necrosis factor inhibitor; MTX: methotrexate; SSZ: sulfasalazine; LEF: leflunomide; csDMARD: conventional synthetic disease-modifying antirheumatic drugs.