Time-dependent analyses (Cox regression analysis for time to MDA); n = 204. Baseline = start of MTX treatment.
| Multivariate Model Covariates | HR | 95% CI | p | Reduced Model | ||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | ||||
| Fixed covariates | ||||||
| Sex, males vs females | 1.16 | (0.94, 1.43) | 0.18 | — | — | — |
| Duration of psoriasis at start of MTX, 1-yr increase | 1.01 | (0.997, 1.01) | 0.20 | — | — | — |
| Duration of PsA at start of MTX, 1-yr increase | 0.99 | (0.98, 1.01) | 0.46 | — | — | — |
| Sacroiliitis at start of MTX | 1.07 | (0.83, 1.39) | 0.60 | — | — | — |
| Time-dependent covariates starting from baseline | ||||||
| ESR, 1-unit increase | 0.997 | (0.99, 1.01) | 0.51 | — | — | — |
| Nail disease, yes vs no | 0.95 | (0.78, 1.17) | 0.64 | — | — | — |
| Dactylitis, yes vs no | 0.62 | (0.40, 0.98) | 0.04 | 0.62 | (0.39, 0.97) | 0.04 |
| Clinically damaged joints, 1-unit increase | 0.99 | (0.98, 1.01) | 0.23 | — | — | — |
| BMI, 1-unit increase | 0.99 | (0.97, 1.01) | 0.32 | — | — | — |
| Inflammatory back pain, yes vs no | 0.41 | (0.25, 0.67) | 0.004 | 0.40 | (0.24, 0.65) | 0.002 |
| Mechanical back pain, yes vs no | 0.52 | (0.37, 0.73) | 0.0002 | 0.51 | (0.36, 0.71) | < 0.0001 |
MDA: minimal disease activity; MTX: methotrexate; PsA: psoriatic arthritis; ESR: erythrocyte sedimentation rate; BMI: body mass index.