Symptoms at tocilizumab (TCZ) introduction and discontinuation for 34 patients with giant cell arteritis (GCA).
| At TCZ Introduction | Tx Length, mos | At TCZ Discontinuation/Last Infusion | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Pt. | Clinical symptoms | CRP level, mg/l | GC, mg/day | MTX, mg/week | Clinical symptoms | CRP level, mg/l | GC, mg/day | MTX, mg/week | |
| 1 | Headache, asthenia, scalp tenderness, jaw claudication | 3 | 30 | 21 | 0 | 5 | |||
| 2 | Headache, jaw claudication | 9 | 20 | 6 | Peripheral arthralgia | 2 | 7 | ||
| 3 | Asthenia, visual symptoms | 1 | 30 | 8 | 1 | 7 | |||
| 4 | Fever, asthenia, PMR, peripheral arthralgia | 30 | 20 | 6 | Asthenia | 1 | 15 | ||
| 5 | Asthenia, weight loss, scalp tenderness | 26 | 40 | 6 | Asthenia | 1 | 5 | ||
| 6 | Asthenia, weight loss, scalp tenderness | 30 | 20 | 12.5 | 3 | 6 | 15 | 12.5 | |
| 7 | Asthenia, headache, scalp tenderness | 15 | 40 | 12.5 | 3 | 3 | 2.5 | 12.5 | |
| 8 | PMR | 60 | 30 | 6 | 1 | 5 | |||
| 9 | Asthenia | 6 | 10 | 3 | 0 | 9 | |||
| 10 | Asthenia | 35 | 20 | 18 | Peripheral arthralgia | 0 | 8 | 20 | |
| 11 | Asthenia, headache | 45 | 20 | 17.5 | 6 | 0 | 5 | 15 | |
| 12 | Asthenia | 19 | 20 | 25 | 12 | 1.1 | 5 | 25 | |
| 13 | Asthenia, headache | 1.9 | 20 | 25 | 3 | 0 | 15 | 25 | |
| 14 | Headache | 20 | 7 | 15 | 8 | Headache | 1 | 15 | 15 |
| 15 | Asthenia, headache, PMR | 8 | 14 | 5 | 1 | 4 | |||
| 16 | Asthenia, headache, PMR | 184 | 3.3* | 6 | 1 | 0.3* | |||
| 17 | Asthenia, headache | 31 | 20 | 12 | 1 | 5 | |||
| 18 | Asthenia, PMR | 20 | 30 | 1 | 1 | 15 | |||
| 19 | Asthenia, headache | 57 | 25 | 15 | 5 | 0 | 6.5 | 15 | |
| 20 | Asthenia, PMR | 20 | 15 | 15 | 10 | 1 | 3 | 15 | |
| 21 | PMR, jaw claudication | 20 | 20 | 20 | 4 | 0 | 12.5 | 20 | |
| 22 | Fever, PMR | 94 | 8 | 6 | PMR | 1 | 7 | ||
| 23 | None | 4 | 30 | 20 | 6 | 0 | 10 | ||
| 24 | Scalp tenderness, PMR | 35 | 60 | 20 | 2 | 2 | 40 | 20 | |
| 25 | Asthenia, PMR | 94 | 20 | 3 | 0.6 | 5 | |||
| 26 | Asthenia, PMR, visual symptoms | 4 | 60 | 12.5 | 6 | 0.6 | 5 | 12.5 | |
| 27 | Scalp necrosis | 100 | 20 | 12.5 | 3 | 5 | 15 | 12.5 | |
| 28 | Asthenia, headaches, jaw claudication | 20 | 40 | 12.5 | 3 | 3 | 17.5 | 12.5 | |
| 29 | Asthenia, headaches | 30 | 20 | 12.5 | 6 | 2 | 5 | 12.5 | |
| 30 | Asthenia, headache, jaw claudication | 30 | 15 | 12.5 | 4 | 6 | 15 | 12.5 | |
| 31 | Asthenia, headache, jaw claudication | 50 | 25 | 12.5 | 3 | 5 | 7.5 | 12.5 | |
| 32 | Asthenia, headache, jaw claudication | 1 | 20 | 6 | 0 | 7 | |||
| 33 | Asthenia, headache, jaw claudication, visual symptoms | 92 | 60 | 15 | 0 | 5 | |||
| 34 | Asthenia, loss of weight | 180 | 40 | 12.5 | 2 | 4 | 35 | 12.5 | |
↵* Patient received betamethasone. 0.75 mg betamethasone = 5 mg prednisone. GC: glucocorticoids; CRP: C-reactive protein; MTX: methotrexate; PMR: polymyalgia rheumatica.