Table 3.

Multivariate logistic regression models to estimate the associations among baseline variables that are potential predictors of remission by the Boolean criteria, DAS28, SDAI, CDAI, RAPID3, and RAPID3-SJ1 at 6 and/or 12 months. Disease duration, erosive at baseline, CRP, ACPA, and RF were not significant in univariate analysis for any of the criteria and were not included in the multivariate analysis.

Baseline
Variables
Boolean Criteria, n = 165 (24.8%)DAS28 ≤ 2.6, n = 339 (51.4%)SDAI ≤ 3.3, n = 204 (30.8%)CDAI ≤ 2.8, n = 205 (30.9%)RAPID3 ≤ 3, n = 273 (41.1%)RAPID3 ≤ 3 + SJ ≤ 1, n = 209 (31.5%)
OR (95% CI)pOR (95% CI)pOR (95% CI)pOR (95% CI)pOR (95% CI)pOR (95% CI)p
Age, yrs0.97 (0.95–0.98)< 0.0010.98 (0.97–0.99)0.010.96 (0.95–0.98)< 0.0010.97 (0.95–0.98)< 0.0010.98 (0.97–0.99)0.0040.97 (0.96–0.98)< 0.001
FemaleNSNS0.59 (0.39–0.87)0.009NSNSNSNSNSNSNSNS
Family history of RA, yes = 1NSNS0.58 (0.37–0.92)0.02NSNSNSNSNSNS0.65 (0.39–1.08)0.09
TJC, 0–280.96 (0.93–0.99)0.030.95 (0.92–0.97)< 0.0010.94 (0.91–0.98)0.0010.93 (0.90–0.96)< 0.0011.00 (0.98–1.03)0.690.98 (0.94–1.00)0.14
SJC, 0–281.02 (0.97–1.07)0.39NSNS1.00 (0.96–1.05)0.691.01 (0.97–1.05)0.54NSNS1.01 (0.97–1.06)0.55
PGA, 0–1000.99 (0.98–1.00)0.060.99 (0.99–1.00)0.550.99 (0.97–0.99)0.030.98 (0.97–0.99)0.011.00 (0.99–1.01)0.630.99 (0.98–1.00)0.38
ESRNSNS0.99 (0.99–1.00)0.28NSNSNSNSNSNSNSNS
Function, 0–101.02 (0.92–1.13)0.660.98 (0.90–1.08)0.771.02 (0.93–1.13)0.611.04 (0.94–1.14)0.760.89 (0.81–0.98)0.010.93 (0.84–1.02)0.11
Pain, 0–1000.99 (0.98–0.99)0.030.99 (0.98–0.99)0.040.98 (0.97–0.99)0.0020.98 (0.97–0.99)0.0020.98 (0.97–0.98)< 0.0010.98 (0.97–0.99)0.004
PtGA, 0–1000.99 (0.98–1.00)0.750.99 (0.99–1.00)0.481.00 (0.99–1.01)0.660.99 (0.98–1.00)0.360.99 (0.99–1.00)0.620.99 (0.99–1.00)0.99
  • DAS28: Disease Activity Score at 28 joints; SDAI: Simplified Disease Activity Index; CDAI: Clinical Disease Activity Index; RAPID3: Routine Assessment of Patient Index Data 3; SJ: swollen joint; CRP: C-reactive protein; ACPA: anticitrullinated protein antibodies; RF: rheumatoid factor; RA: rheumatoid arthritis; TJC: tender joint count; SJC: swollen joint count; PGA: physician’s global assessment; ESR: erythrocyte sedimentation rate; PtGA: patient’s global assessment; NS: variables not significant in univariate analysis and therefore not included in multivariate analysis for each specific criteria set.