Table 2.

Genotyped and imputed SNP at 1q23 associated with response to cyclophosphamide treatment for lupus nephritis.

SNPPositionLocation1 > 2*Nonresponders, n = 16Responders, n = 93ptrend
11/12/22*MAF11/12/22*MAF
rs1809781551615870166 kb 3′ of FCGR3BG > A12/4/00.1393/0/00.009.0 × 10−7
rs66963969161594822Intron of FCGR3BA > –12/4/00.1393/0/00.009.0 × 10−7
rs149686267161600109Intron of FCGR3BC > T12/4/00.1393/0/00.009.0 × 10−7
rs349072911616015390.4 kb 5′ of FCGR3BG > C12/4/00.1393/0/00.009.0 × 10−7
rs127563981616069266 kb 5′ of FCGR3BT > A12/4/00.1393/0/00.009.0 × 10−7
rs17411858†16161751613 kb 5′ of FCGR2BA > G12/3/10.1693/0/00.003.6 × 10−6
rs177156816161987413 kb 5′ of FCGR2BT > G12/4/00.1393/0/00.009.0 × 10−7
rs1091768616165849010 kb 3′ of FCGR2BC > T11/5/00.1693/0/00.003.4 × 10−8
rs1091768816165878010 kb 3′ of FCGR2BC > T11/5/00.1693/0/00.003.4 × 10−8
rs6697139†16166069612 kb 3′ of FCGR2BG >T11/5/00.1693/0/00.003.4 × 10−8
rs1130537701616724744 kb 5′ of FCRLAC > T12/4/00.1393/0/00.009.0 × 10−7

  • ↵* Major and minor alleles are denoted as 1 and 2, respectively.

  • ↵† These 2 SNP were genotyped and the others were imputed among the 11 SNP showing ptrend < 1 × 10−5. SNP: single-nucleotide polymorphism; MAF: minor allele frequency.