Table 2.

HR estimates of anti-TNF discontinuation at 4 years by univariate and multivariate Cox regression analysis.

	Univariate			Multivariate
Baseline covariates	HR	95% CI	p	HR	95% CI	p
Age	0.99	0.98–1.00	0.79	0.99	0.98–1.01	0.88
Sex, female/male	1.75	1.20–2.36	0.001	2.02	1.28–3.20	0.002
Disease duration	0.97	0.94–1.00	0.64	0.96	0.93–0.99	0.02
Oligo/polyarticular	0.78	0.58–1.05	0.11	1.20	0.73–1.99	0.45
CRP, ≥ 1 mg/dl / < 1 mg/dl	0.93	0.67–1.29	0.67	1.29	0.83–1.89	0.25
68-tender joint count	1.01	1.00–1.02	0.04	1.00	0.98–1.02	0.71
66-swollen joint count	1.00	0.97–1.03	0.74	0.99	0.95–1.03	0.75
HAQ	1.20	0.97–1.48	0.79	1.16	0.85–1.59	0.32
Calendar year	1.02	0.97–1.07	0.36	1.06	0.99–1.13	0.94
DMARD, yes/no	1.03	0.77–1.38	0.80	0.89	0.61–1.30	0.65
Prednisone, yes/no	1.00	0.76–1.33	0.96	1.08	0.74–1.58	0.65
Drug
Infliximab	1
Adalimumab	1.10	0.77–1.58	0.58	0.93	0.56–1.54	0.79
Etanercept	0.68	0.48–0.98	0.04	0.57	0.34–0.93	0.02

TNF: tumor necrosis factor; CRP: C-reactive protein; HAQ: Health Assessment Questionnaire; DMARD: disease-modifying antirheumatic drug.