Association between serological profile and clinical characteristics in SSc. Chi-square or 1-way ANOVA was conducted to make association analysis between categorical variables or categorical continuous variables. P value < 0.05 was considered a significant association. Corresponding OR and 95% CI are shown in Supplementary Table 5 (available from the authors on request).
| Characteristics | ANA | ATA | ACA | Anti-RNAP 3 | ARA | Anti-Sm | SSA | SSB | Anti-PM-1 | RF |
|---|---|---|---|---|---|---|---|---|---|---|
| Sex | 0.3223 | 0.6592 | 0.1294 | 0.8778 | 0.003 | 0.1394 | 0.8701 | 0.5802 | 0.6897 | 0.5517 |
| lcSSc/dcSSc | 1 | 0.025 | 0.0165 | 0.0902 | 0.0105 | 0.2184 | 0.061 | 0.017 | 0.0585 | 0.1714 |
| CREST | 1 | 1 | 1 | 0.0198 | 0.0145 | 0.2599 | 0.2024 | 1 | 0.1979 | 1 |
| Lung | 0.7411 | 0.0205 | 0.026 | 0.8646 | 0.4398 | 0.1709 | 0.8726 | 0.08 | 1 | 0.3983 |
| Heart | 0.5132 | 1 | 0.8106 | 0.2396 | 0.7251 | 0.7676 | 0.3678 | 0.4733 | 1 | 0.8406 |
SSc: systemic sclerosis; ANA: antinuclear antibodies; ATA: anti-DNA topoisomerase I antibody; ACA: anticentromere antobodies; anti-RNAP 3: anti-RNA polymerase 3 antibodies; ARA: anti-U1RNP; RF: rheumatoid factor; lcSSc: limited cutaneous SSc; dcSSc: diffuse cutaneous SSc; CREST (syndrome): calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias.