Age at onset and enrollment, and distribution of JIA categories between AA and NHW subjects in the CARRA Registry and Emory cohort. There were 291 AA subjects and 4148 NHW subjects with JIA in the CARRA Registry. There were 71 AA subjects and 212 NHW subjects with JIA in the Emory cohort. Values are n (%) unless otherwise specified.
| Categories | CARRA Registry | Emory** | ||||||
|---|---|---|---|---|---|---|---|---|
| AA | NHW | OR (95% CI) | p* | AA | NHW | OR (95% CI) | p | |
| Age at onset^ | 8.9 | 5.2 | 1.27 × 10−11 | 9.1 | 6.1 | 0.009 | ||
| Age at enrollment^ | 9.6 | 6.5 | 4.26 × 10−11 | 9.8 | 6.6 | 0.011 | ||
| Systemic JIA | 43 (14.8) | 292 (7.0) | 2.29 (1.58–3.25) | 0.0003 | 8 (11.3) | 13 (6.1) | 1.94 (0.66–5.23) | 0.189 |
| Polyarthritis RF− | 72 (24.7) | 1283 (30.9) | 0.73 (0.55–0.97) | 0.5031 | 15 (21.1)** | 50 (23.6)** | 0.87 (0.42–1.72)** | 0.746** |
| Polyarthritis RF+ | 39 (13.4) | 196 (4.7) | 3.12 (2.10–4.53) | 5.3 × 10−7 | 19 (26.8) | 13 (6.1) | 5.55 (2.42–13.10) | 1.1 × 10−5 |
| Oligoarticular JIA | 76 (26.1) | 1546 (37.2) | 0.59 (0.45–0.78) | 0.0023 | 19 (26.8) | 92 (43.4) | 0.48 (0.26–0.86) | 0.014 |
| Persistent | 63 (21.7) | 1218 (29.4) | 0.66 (0.49–0.89) | 0.0827 | 8 (11.3)** | 68 (32.1)** | 0.27 (0.11–0.61)** | 5.7 × 10−4** |
| Extended | 13 (4.5) | 328 (7.9) | 0.54 (0.28–0.96) | 0.5162 | 11 (15.5)** | 24 (11.3)** | 1.43 (0.60–3.26)** | 0.405** |
| Psoriatic | 6 (2.1) | 265 (6.4) | 0.31 (0.11–0.69) | 0.0233 | 1 (1.4) | 10 (4.7) | 0.29 (0.01–2.10) | 0.301 |
| ERA | 36 (12.4) | 419 (10.1) | 1.26 (0.85–1.82) | 1.0000 | 7 (9.9)** | 29 (13.7)** | 0.69 (0.24–1.72)** | 0.537** |
| Undifferentiated | 8 (2.8) | 105 (2.5) | 1.09 (0.45–2.25) | 1.0000 | 2 (2.8)** | 5 (2.4)** | 1.2 (0.11–7.53)** | 1.000** |
Significant data are in bold face.
↵* P values are reported after multiple-hypothesis correction. Multiple-testing correction was performed by applying a Bonferroni correction based on the effective number of independent tests (17) in our sample.
↵^ Age at onset and enrollment of all cases with JIA are reported in median years.
↵** Entries from the Emory study represent tests that were not part of the replication; we include these values strictly for informative purposes. JIA: juvenile idiopathic arthritis; AA: African American; NHW: non-Hispanic white; CARRA: Childhood Arthritis and Rheumatology Research Alliance; RF: rheumatoid factor; ERA: enthesitis-related arthritis.