Clinical characteristics at followup for patients achieving remission after 3 and 6 months. Values are % or mean (95% CI) unless otherwise specified.
| Characteristics | Remission 3 Mos | Remission 6 Mos | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DAS28 | CDAI | SDAI | RAPID3 | ACR/EULAR Boolean | ACR/EULAR Boolean Practice | DAS28 | CDAI | SDAI | RAPID3 | ACR/EULAR Boolean | ACR/EULAR Boolean Practice | |
| Patients, n (%) | 962 (22.5) | 494 (10.3) | 434 (9.8) | 979 (20.3) | 425 (8.7) | 510 (10.3) | 883 (26.0) | 478 (12.6) | 415 (11.8) | 817 (21.3) | 392 (10.1) | 477 (12.2) |
| mHAQ | 0.20 (0.18–0.21) | 0.09 (0.07–0.11) | 0.10 (0.08–0.12) | 0.06 (0.05–0.06) | 0.09 (0.07–0.11) | 0.10 (0.08–0.12) | 0.19 (0.17–0.21) | 0.09 (0.07–0.10) | 0.09 (0.07–0.11) | 0.05 (0.04–0.15) | 0.10 (0.08–0.12) | 0.09 (0.08–0.11) |
| PtGA, 0–100 | 17.2 (16.2–18.1) | 7.8 (7.2–8.4) | 7.4 (4.0–8.0) | 7.1 (6.8–7.4) | 6.3 (5.9–6.7) | 6.3 (5.9–6.7) | 16.6 (15.6–17.6) | 6.9 (5.4–7.5) | 7.2 (6.6–7.8) | 6.8 (6.4–7.1) | 5.9 (5.5–6.3) | 5.9 (5.5–6.3) |
| PtGA ≤ 1, 0–10 | 53.7 | 84.3 | 86.2 | 91.8 | 100 | 100 | 54.1 | 87.4 | 85.5 | 90.3 | 100 | 100 |
| PGA, 0–100 | 10.2 (9.7– 10.7) | 5.0 (4.6–5.4) | 5.3 (4.9–5.6) | 11.5 (10.8–12.1) | 6.6 (6.1–7.2) | 6.9 (6.3–7.4) | 9.0 (8.5–9.5) | 4.6 (4.2–4.9) | 4.4 (4.1–4.8) | 9.7 (9.2–10.2) | 5.7 (5.2–6.2) | 6.1 (5.6–6.6) |
| Pain, 0–100 | 16.1 (15.1– 17.1) | 7.8 (7.0–8.6) | 7.6 (6.9–8.4) | 6.1 (5.8–6.4) | 7.2 (6.5–8.0) | 7.2 (6.5–7.8) | 15.6 (14.4–16.6) | 7.6 (6.9–8.2) | 7.9 (7.1–8.6) | 5.6 (5.4–6.0) | 7.0 (6.2–7.7) | 6.9 (6.2–7.5) |
| Fatigue, 0–100 | 28.2 (26.5–29.8) | 20.2 (18.1–22.4) | 19.1 (17.2–21.1) | 17.1 (15.8–18.3) | 18.6 (16.5–20.7) | 18.1 (16.2–20.0) | 25.4 (23.8–27.1) | 15.7 (14.0–17.4) | 15.9 (14.1–17.7) | 14.9 (13.6–16.2) | 15.6 (13.7–17.6) | 16.0 (14.1–17.8) |
| SJC28 | 1.0 (0.9–1.1) | 0.1 (0.1–0.2) | 0.1 (0.1–0.1) | 2.0 (1.8–2.2) | 0.2 (0.2–0.3) | 0.2 (0.2–0.2) | 0.8 (0.7–0.9) | 0.1 (0.1–0.2) | 0.1 (0.1–0.2) | 1.7 (1.5–1.8) | 0.2 (0.2–0.3) | 0.2 (0.2–0.2) |
| SJC28 ≤ 1 | 76.7 | 98.2 | 98.8 | 59.4 | 100 | 100 | 82.2 | 98.5 | 98.6 | 63.2 | 100 | 100 |
| TJC28 | 0.6 (0.5 –0.6) | 0.2 (0.1–0.2) | 0.1 (0.1–0.2) | 1.4 (1.3–1.5) | 0.2 (0.2–0.3) | 0.2 (0.2–0.3) | 0.5 (0.4–0.6) | 0.1 (0.1–0.2) | 0.1 (0.1–0.2) | 1.2 (1.0–1.3) | 0.2 (0.2–0.3) | 0.2 (0.2–0.3) |
| TJC28 ≤ 1 | 86.0 | 98.8 | 99.2 | 68.0 | 100 | 100 | 87.1 | 99.0 | 98.6 | 73.0 | 100 | 100 |
| CRP, mg/l | 4.7 (4.4–5.1) | 4.3 (4.0–4.6) | 6.5 (5.5–7.5) | 6.8 (6.2–7.5) | 4.6 (4.2–4.9) | 6.5 (5.5–7.5) | 4.4 (4.1–4.8) | 5.2 (4.5–5.9) | 3.8 (3.4–4.1) | 6.7 (6.0–7.4) | 3.8 (3.5–4.1) | 5.5 (4.8–6.2) |
| CRP ≤ 1, mg/dl | 96.1 | 93.1 | 98.4 | 90.1 | 100 | 93.6 | 96.2 | 93.7 | 98.3 | 89.7 | 100 | 92.2 |
| DAS28 | 1.9 (1.9–2.0) | 1.7 (1.7–1.8) | 1.8 (1.7–1.9) | 2.5 (2.4–2.5) | 1.8 (1.8–1.9) | 1.9 (1.8–1.9) | 1.9 (1.8–1.9) | 1.7 (1.6–1.8) | 1.7 (1.6–1.7) | 2.4 (2.3–2.4) | 1.7 (1.7–1.8) | 1.8 (1.7–1.9) |
| SDAI | 4.8 (4.6–5.0) | 2.0 (1.9–2.1) | 2.2 (2.0–2.3) | 6.0 (5.6–6.3) | 2.2 (2.1–2.3) | 2.4 (2.3–2.6) | 4.3 (4.1–4.5) | 2.0 (1.9–2.1) | 1.8 (1.7–1.9) | 5.3 (4.9–5.6) | 2.0 (1.8–2.1) | 2.2 (2.0–2.3) |
| CDAI | 4.3 (4.1–4.5) | 1.6 (1.5–1.6) | 1.5 (1.5–1.6) | 5.3 (4.9–5.6) | 1.8 (1.6–1.9) | 1.8 (1.7–1.9) | 3.9 (3.7–4.1) | 1.4 (1.4–1.5) | 1.4 (1.4–1.5) | 4.5 (4.2–4.8) | 1.6 (1.5–1.7) | 1.6 (1.5–1.7) |
| RAPID3 | 1.3 (1.3–1.4) | 0.6 (0.6–0.7) | 0.6 (0.6–0.7) | 0.5 (0.5–0.5) | 0.5 (0.5–0.6) | 0.6 (0.5–0.6) | 1.3 (1.2–1.4) | 0.6 (0.5–0.6) | 0.6 (0.6–0.7) | 0.5 (0.4–0.5) | 0.5 (0.5–0.6) | 0.5 (0.5–0.6 |
DAS28: Disease Activity Score at 28 joints; CDAI: Clinical Disease Activity Index; SDAI: Simplified Disease Activity Index; RAPID3: Routine Assessment of Patient Index Data; ACR: American College of Rheumatology; EULAR: European League Against Rheumatism; ACR/EULAR Boolean: ACR/EULAR Boolean remission definition; ACR/EULAR Boolean Practice: ACR/EULAR Boolean remission definition for clinical practice; mHAQ: modified Health Assessment Questionnaire; PtGA: patient’s global assessment; PGA: physician’s global assessment; SJC28: swollen joint count at 28 joints; TJC28: tender joint count at 28 joints; CRP: C-reactive protein.