Association of LTL with incident RA risk by time since blood draw to diagnosis in the Nurses’ Health Studies and the Women’s Health Study combined*.
| Variables | < 4 Yrs | 4 to < 8 Yrs | 8+ Yrs | phet | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Ca/Co, n | OR | 95% CI | Ca/Co, n | OR | 95% CI | Ca/Co, n | OR | 95% CI | ||
| Shortest tertile | 13/52 | 1.00 | 28/83 | 1.00 | 31/115 | 1.00 | ||||
| Intermediate | 26/71 | 1.13 | 0.18–7.16 | 31/89 | 1.06 | 0.32–3.51 | 41/92 | 1.58 | 0.94–2.67 | |
| Longest tertile | 34/80 | 1.78 | 0.83–3.80 | 29/78 | 1.21 | 0.64–2.29 | 51/105 | 1.78 | 1.08–2.95 | |
| Per SD** | 1.20 | 0.91–1.59 | 1.14 | 0.87–1.48 | 1.22 | 1.00–1.49 | ||||
| ptrend† | 0.19 | 0.35 | 0.05 | 0.85 | ||||||
↵* Metaanalysis used to combine estimates from unconditional logistic regression adjusted for the same covariates listed in Table 2.
↵** Nurses’ Health Study LTL SD = 0.26; Women’s Health Study LTL SD = 0.71.
↵† Based on per SD analysis. LTL: leukocyte telomere length; RA: rheumatoid arthritis; Ca: cases; Co: controls; phet: pheterogeneity.