Sensitivity, specificity, PPV, and NPV of the suggested criteria compared with previous criteria (including only patients with biallelic mutations in exon 10).
| Criteria | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) |
|---|---|---|---|---|---|
| Yalcinkaya-Ozen | |||||
| 1 criterion | 99.5 | 5.7 | 44.3 | 93.8 | 46.0 |
| 2 criteria | 90.4 | 40.7 | 53.4 | 84.9 | 62.0 |
| 3 criteria | 64.1 | 88.2 | 80.4 | 76.6 | 77.8 |
| 4 criteria | 33.3 | 99.6 | 98.5 | 66.5 | 71.1 |
| 5 criteria | 8.1 | 99.6 | 94.1 | 59.0 | 60.3 |
| Tel Hashomer criteria | 49.7 | 97.2 | 91.9 | 75.1 | 78.6 |
| Without colchicine response | 24.0 | 99.6 | 97.8 | 67.1 | 70.1 |
| Livneh criteria | 77.3 | 41.1 | 49.7 | 70.6 | 56.6 |
FMF group (n = 198), control group (n = 263), for Yalcinkaya-Ozen criteria. FMF group (n = 183), control group (n = 285), for Tel Hashomer criteria. FMF group (n = 198), control group (n = 263), for Livneh criteria. FMF: familial Mediterranean fever; PPV: positive predictive values; NPV: negative predictive values.