Elevated levels of IL-6, IL-8, TNF-α, and MCP-1 proteins (pg/ml) in plasma from children with untreated JDM. IL-6, IL-8, TNF-α, and MCP-1 levels in plasma from children with untreated JDM (n = 15) and healthy pediatric controls (n = 5) were assayed using a human ProInflammatory 4-II Ultra-Sensitive Kit and a human MCP-1 Ultra-Sensitive Kit from MesoScale Discovery. Student t test was used for statistical analysis. P < 0.05 was considered significant. Values are mean ± SD.
| Variable | Control, n = 5 | JDM, n = 15 | p |
|---|---|---|---|
| IL-6 | 0.93 ± 1.47 | 1.93 ± 1.55 | 0.0363 |
| IL-8 | 2.69 ± 4.65 | 9.57 ± 5.79 | 0.0005 |
| TNF-α | 3.08 ± 6.33 | 9.42 ± 5.71 | 0.0011 |
| MCP-1 | 126.51 ± 28.63 | 835.56 ± 976.37 | 0.0139 |
IL: interleukin; TNF-α: tumor necrosis factor-α; MCP-1: monocyte chemoattractant protein 1; JDM: juvenile dermatomyositis.