Maternal disease activity by outcome for pregnancies from clinical trial reports: CD and RA subgroups*. Range of CDAI index: 0–600, remission < 150, low disease activity 150–219, moderate disease activity 220–450, and high disease activity > 450. Range of DAS28-ESR index: 0–10, remission ≤ 2.6, low disease activity > 2.6 to ≤ 3.2, moderate disease activity > 3.2 to ≤ 5.1, and high disease activity > 5.1.
| CD | Live Birth, n = 6 | Miscarriage, n = 2 | Induced Abortion, n = 4 | Total, n = 12 |
| CDAI at baseline, CD study entry | ||||
| Mean (SD) | 280.3 (42.0) | 296.0 (7.2) | 320.1 (47.8) | 296.2 (42.1) |
| Median | 275.4 | 296.0 | 304.9 | 288.8 |
| Min, max | 223, 347 | 291, 301 | 284, 387 | 223, 387 |
| CDAI at visit prior to pregnancy report | ||||
| Mean (SD) | 180.5 (100.9) | 151.4 (2.3) | 168.8 (99.3) | 171.7 (86.2) |
| Median | 200.3 | 151.4 | 163.2 | 175.8 |
| Min, max | 34, 304 | 150, 153 | 72, 277 | 34, 304 |
| CDAI change from baseline | ||||
| Mean (SD) | −99.9 (74.1) | −144.6 (9.6) | −151.3 (84.7) | −124.5 (71.6) |
| Median | −86.2 | −144.6 | −147.9 | −123.9 |
| Min, max | −189, 1 | −151, −138 | −251, −58 | −251, 1 |
| RA | Live Birth, n = 7 | Miscarriage, n = 4 | Induced Abortion, n = 3 | Total, n = 14 |
| DAS28-ESR at baseline, RA study entry | ||||
| Mean (SD) | 6.4 (0.8) | 6.1 (0.7) | 6.6 (0.9) | 6.4 (0.8) |
| Median | 6.2 | 6.1 | 6.6 | 6.2 |
| Min, max | 5.1, 7.3 | 5.4, 7.0 | 5.8, 7.6 | 5.1, 7.6 |
| DAS28-ESR at visit prior to pregnancy report | ||||
| Mean (SD) | 3.5 (1.7) | 2.4 (1.4) | 4.4 (1.1) | 3.4 (1.6) |
| Median | 2.7 | 1.9 | 4.2 | 2.9 |
| Min, max | 2.2, 6.3 | 1.3, 4.5 | 3.4, 5.6 | 1.3, 6.3 |
| DAS28-ESR change from baseline | ||||
| Mean (SD) | −2.9 (1.6) | −3.7 (1.6) | −2.2 (0.8) | −3.0 (1.5) |
| Median | −3.0 | −4.0 | −2.1 | −3.0 |
| Min, max | −4.7, −0.6 | −5.2, −1.6 | −3.1, −1.6 | −5.2, −0.6 |
↵* Includes pregnancies collected between July 12, 2001 and March 28, 2013. CD: Crohn disease; RA: rheumatoid arthritis; CDAI: Crohn’s Disease Activity Index; DAS28: 28-joint Disease Activity Score; ESR: erythrocyte sedimentation rate.