Table 1.

Frequency of anti-DFS70 antibodies in pediatric cohorts.

CohortnDFS70-positive, nDFS70-positive, %p
Reference cohorts, n = 345
  ANA referrals, qCTD*20094.5NS
AARD, n = 383
  Diffuse cSSc2214.5NS
  Limited cSSc1900.0NS
Other inflammatory conditions, n = 360
  JIA without uveitis18331.6NS
  JIA with uveitis19210.5NS
  Celiac disease4924.1NS
  Localized scleroderma29413.80.0310
  Idiopathic uveitis7114.3NS
  Reactive arthritis2100.0NS
  • * Sera referred for an ANA/ENA test as part of the investigations for qCTD. Sera were from children ≤ 18 years of age.

  • ** Cases of Crohn disease, Reiter syndrome, panniculitis, sarcoidosis, primary antiphospholipid syndrome, viral myopathy, eosinophilic fasciitis.

  • P value is calculated against healthy individuals by Student t test. DFS70: dense fine speckled 70 kDa antigen; ANA: antinuclear antibody; AARD: ANA-associated rheumatic disease; qCTD: query connective tissue disease (children being investigated for an AARD); cSLE: childhood systemic lupus erythematosus; cSSc: childhood systemic sclerosis; JIA: juvenile idiopathic arthritis; NA: not applicable; NS: not statistically significant; JDM: juvenile dermatomyositis.