Frequency of anti-DFS70 antibodies in pediatric cohorts.
| Cohort | n | DFS70-positive, n | DFS70-positive, % | p† |
|---|---|---|---|---|
| Reference cohorts, n = 345 | ||||
| ANA referrals, qCTD* | 200 | 9 | 4.5 | NS |
| Healthy | 145 | 3 | 2.1 | NA |
| AARD, n = 383 | ||||
| cSLE | 331 | 19 | 5.7 | NS |
| JDM | 11 | 2 | 18.2 | NS |
| Diffuse cSSc | 22 | 1 | 4.5 | NS |
| Limited cSSc | 19 | 0 | 0.0 | NS |
| Other inflammatory conditions, n = 360 | ||||
| JIA without uveitis | 183 | 3 | 1.6 | NS |
| JIA with uveitis | 19 | 2 | 10.5 | NS |
| Arthralgia | 32 | 0 | 0.0 | NS |
| Celiac disease | 49 | 2 | 4.1 | NS |
| Localized scleroderma | 29 | 4 | 13.8 | 0.0310 |
| Idiopathic uveitis | 7 | 1 | 14.3 | NS |
| Reactive arthritis | 21 | 0 | 0.0 | NS |
| Other** | 20 | 0 | 0.0 | NS |
↵* Sera referred for an ANA/ENA test as part of the investigations for qCTD. Sera were from children ≤ 18 years of age.
↵** Cases of Crohn disease, Reiter syndrome, panniculitis, sarcoidosis, primary antiphospholipid syndrome, viral myopathy, eosinophilic fasciitis.
↵† P value is calculated against healthy individuals by Student t test. DFS70: dense fine speckled 70 kDa antigen; ANA: antinuclear antibody; AARD: ANA-associated rheumatic disease; qCTD: query connective tissue disease (children being investigated for an AARD); cSLE: childhood systemic lupus erythematosus; cSSc: childhood systemic sclerosis; JIA: juvenile idiopathic arthritis; NA: not applicable; NS: not statistically significant; JDM: juvenile dermatomyositis.