Demographic and clinical characteristics of patients with GPA during the 12-month pre-period and 12-month followup.
| Pre-period Incident GPA, n = 569 | Total GPA, n = 2784 | 12-month Followup Incident GPA, n = 569 | Prevalent GPA, n = 2215 | |
|---|---|---|---|---|
| Age, yrs, mean (SD) | 56.4 (15.1) | 57.9 (15.1) | 56.0 (15.0) | |
| Age group, n (%) | ||||
| 18–34 | 262 (9.4) | 40 (7.0) | 222 (10.0) | |
| 35–44 | 322 (11.6) | 70 (12.3) | 252 (11.4) | |
| 45–54 | 530 (19.0) | 101 (17.7) | 429 (19.4) | |
| 55–65 | 916 (32.9) | 177 (31.1) | 739 (33.4) | |
| 65+ | 754 (27.1) | 181 (31.8) | 573 (25.9) | |
| Male, n (%) | 1272 (45.7) | 278 (48.9) | 994 (44.9) | |
| Geographic region, n (%) | ||||
| Northeast | 606 (21.8) | 119 (20.9) | 487 (22.0) | |
| North central | 779 (28.0) | 171 (30.1) | 608 (27.4) | |
| South | 852 (30.6) | 167 (29.3) | 685 (30.9) | |
| West | 518 (18.6) | 107 (18.8) | 411 (18.6) | |
| Unknown | 29 (1.0) | 5 (0.9) | 24 (1.1) | |
| Mean (SD) Deyo Charlson Comorbidity Index* | 1.3 (1.6) | 1.6 (1.9) | 1.8 (1.9) | 1.5 (1.9) |
| Diagnoses of major relapse-associated conditions based on BVAS*, n (%) | ||||
| Acute/chronic renal failure | 132 (23.2) | 864 (31.0) | 209 (36.7) | 655 (29.6) |
| Gangrene | 1 (0.2) | 8 (0.3) | 4 (0.7) | 4 (0.2) |
| Scleritis | 9 (1.6) | 65 (2.3) | 11 (1.9) | 54 (2.4) |
| Retinal exudates/hemorrhage | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Sensorineural deafness | 33 (5.8) | 192 (6.9) | 41 (7.2) | 151 (6.8) |
| Mesenteric ischemia | 0 (0.0) | 11 (0.4) | 3 (0.5) | 8 (0.4) |
| Lung-related condition | 40 (7.0) | 225 (8.0) | 79 (14.0) | 146 (7.0) |
| Hemoptysis* | 23 (4.0) | 104 (3.7) | 50 (8.8) | 54 (2.4) |
| Respiratory failure | 22 (3.9) | 155 (5.6) | 49 (8.6) | 106 (4.8) |
| Meningitis | 1 (0.2) | 7 (0.3) | 1 (0.2) | 6 (0.3) |
| Cord lesion | 0 (0.0) | 6 (0.2) | 2 (0.4) | 4 (0.2) |
| Stroke | 9 (1.6) | 43 (1.5) | 11 (1.9) | 32 (1.4) |
| Cranial nerve palsy | 0 (0.0) | 9 (0.3) | 3 (0.5) | 6 (0.3) |
| Sensory peripheral neuropathy | 21 (3.7) | 118 (4.2) | 27 (4.7) | 91 (4.1) |
| Motor mononeuritis multiplex | 4 (0.7) | 19 (0.7) | 6 (1.1) | 13 (0.6) |
| Relapse during the post-index period | ||||
| Presence of relapse, n (%) | — | 520 (18.7) | 119 (20.9) | 401 (18.1) |
| 1 relapse | — | 370 (13.3) | 71 (12.5) | 299 (13.5) |
| 2–3 relapses | — | 136 (4.9) | 36 (6.3) | 100 (4.5) |
| > 3 relapses | — | 14 (0.5) | 12 (2.1) | 2 (0.1) |
| Mean (SD) no. relapses per patient among patients with at least 1 relapse | — | 1.4 (0.9) | 1.8 (1.4) | 1.3 (0.6) |
↵* Patients with hemoptysis (ICD-9-CM 786.30, 786.39) were identified because no diagnosis codes were available for alveolar hemorrhage. BVAS: Birmingham Vasculitis Activity Score; GPA: granulomatosis with polyangiitis; MPA: microscopic polyangiitis; ICD-9-CM: International Classification of Diseases-9-Clinical Modification.