Modified total Sharp score (mTSS) at baseline and followup visits and annual changes in mTSS for the followup time periods in patients with early rheumatoid arthritis followed for 10 years.
| mTSS at Visit at: | p < 0.05 Between Timepoints | |||||
|---|---|---|---|---|---|---|
| BaselineA, n = 76 | 2 Yrs B, n = 71 | 5 Yrs C, n = 83 | 10 Yrs D, n = 71 | |||
| Mean (SD) | 7.0 (10.2) | 13.8 (20.5) | 17.7 (24.5) | 22.6 (32.1) | All | |
| Median [IQR] | 3.0 [10.0] | 6.0 [15.0] | 9.0 [19.0] | 11.0 [22.0] | All | |
| Annual Change in mTSS for the Periods: | ||||||
| 0–2 Yrs A, n = 66 | 2–5 Yrs B, n = 69 | 5–10 Yrs C, n = 69 | 2–10 Yrs D, n = 57 | 0–10 Yrs, n = 60 | p < 0.05 Between Time Periods | |
| Mean (SD) | 3.4 (6.3) | 1.7 (2.9) | 1.2 (2.7) | 1.3 (2.4) | 1.6 (2.7) | A & B,C,D |
| Median [IQR] | 0.8 [3.5] | 0.3 [2.0] | 0.6 [1.6] | 0.6 [1.6] | 0.9 [1.8] | A & B,C,D |
| Patients with increase in mTSS > 0/yr | 60.6% | 58.0% | 62.3% | 63.2% | 70.0% | A & B,C,D |
| Patients with increase in mTSS > 1/yr | 43.9% | 33.3% | 34.8% | 42.1% | 38.3% | A & B |
| Patients with increase in mTSS > 2/yr | 37.9% | 24.6% | 13.0% | 17.5% | 20.0% | A & B,D |
| Patients with increase in mTSS > SDC | 19.7% | 13.0% | 4.3% | 3.5% | 11.7% | A & B |
IQR: interquartile range; SDC: smallest detectable change > 4.9.