Table 4.

Correlation analysis between presence of FH autoantibodies and clinical manifestations. Table indicates % of FH autoantibody–positive or –negative patients in the 2 cohorts (Serbian and Italian) and disease classifications (PAPS and SAPS) depending on the presence of the indicated manifestations. Disorders are displayed in collective terms and include the following: obstetric disorder including fetal losses; coagulation disorder including arterial or venous thrombosis and cerebral, pulmonary, or renal thrombosis; hematological disorder including hemolytic anemia, leukopenia, lymphopenia, or thrombocytopenia; heart disorder including infarction, unstable angina, vegetations, cardiomyopathy, and valve dysfunctions; neurological disorder including migraine, dementia, and epilepsy; pulmonary disorder including pulmonary hypertension, intraalveolar hemorrhage, and pulmonary microthrombosis; renal disorder including glomerular capillary thrombosis and renal vein thrombosis; cutaneous disorder including skin ulcerations, superficial necrosis, and digital gangrene.

Cohort Patient classificationSerbianItalian
PAPSSAPSPAPSSAPS
a-FHpos/a-FHneg, n10/6310/235/109/16
Manifestationn (% a-FHpos/% a-FHneg)n (% a-FHpos/% a-FHneg)
Obstetric disorder59 (90/79)21 (50/70)3 (20/20)5 (22/19)
Coagulation disorder41 (44/60)22 (70/65)
Hematological disorder6 (40/40)16 (67/63)
Heart disorder13 (40/14)*17 (50/55)
Neurological disorder33 (40/46)25 (60/83)4 (40/20)7 (33/25)
Pulmonary disorder9 (10/13)3 (20/4)
Renal disorder3 (0/5)0 (—/—)1 (20/0)9 (56/25)
Cutaneous disorder17 (30/23)30 (70/100)*1 (0/10)18 (100/56)*
Arthritis5 (10/6)25 (50/87)*0 (—/—)14 (44/63)
  • Significant difference in ratio between manifestation-positive patients in the 2 antibody groups was calculated using Pearson chi-square test and indicated as * p < 0.05. FH: complement factor H; APS: antiphospholipid syndrome; PAPS: primary APS; SAPS: secondary APS; a-FHpos: FH autoantibody–positive; a-FHneg: FH autoantibody–negative.