Cox proportional hazards regression analysis for interaction of gout and comorbidity on risk of ED.
| Gout | Comorbidity‡ | Person-years | Event, n | Rate# | HR (95% CI) | p < 0.001 | |
|---|---|---|---|---|---|---|---|
| Crude | Adjusted† | ||||||
| No | No | 497,796 | 329 | 6.61 | 1 (Reference) | 1 (Reference) | |
| No | Yes | 117,469 | 229 | 19.49 | 2.93 (2.48–3.47)*** | 1.92 (1.61–2.30)*** | |
| Yes | No | 99,955 | 87 | 8.70 | 1.31 (1.04–1.66)* | 1.40 (1.11–1.77)** | |
| Yes | Yes | 50,573 | 99 | 19.58 | 2.89 (2.31–3.62)*** | 2.04 (1.63–2.57)*** | |
↵‡ Patients with any 1 of the comorbidities (diabetes, ischemic heart disease, congestive heart failure, hypertension, depression, and chronic renal disease) were classified as the comorbidity group.
↵# Incidence rate, per 10,000 person-years.
↵† Multivariable analysis including age, gout, and comorbidity (note: patients with any 1 of the comorbidities were classified as the comorbidity group).
↵* p < 0.05.
↵** p < 0.01.
↵*** p < 0.001. ED: erectile dysfunction.