Mortality risk based on the presence of gout and ULT.
| Gout | ULT | n | PY | CVD Mortality | All-cause Mortality | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| E | M | MRR | HR (95% CI) | p | E | M | MRR | HR (95% CI) | p | ||||
| −* | − | 3556 | 22,916 | 25 | 1.09 | Reference | 117 | 5.11 | Reference | ||||
| +* | − | 1189 | 7630 | 21 | 2.75 | 2.52 | 2.43 (1.33–4.45) | < 0.01 | 60 | 7.86 | 1.54 | 1.45 (1.05–2.00) | 0.01 |
| + | − | 764 | 4886 | 16 | 3.27 | Reference | 44 | 9.01 | Reference | ||||
| + | + | 764 | 4966 | 5 | 1.01 | 0.31 | 0.29 (0.11–0.80) | 0.02 | 23 | 4.63 | 0.51 | 0.47 (0.29–0.79) | 0.01 |
↵* HR were adjusted for age, sex, lifestyle (smoking, drinking, and exercise), and comorbidity (obesity, hypertension, diabetes, renal failure, and hepatitis). ULT: urate-lowering therapy; PY: person-years; CVD: cardiovascular disease; E: number of events; M: mortality rate per 1000 person-years; MRR: mortality rate ratio.