Cox proportional hazard regression analysis of predisposing factors for hemorrhagic cystitis occurrence.
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| Ever used mesna | 1.93 (0.72–5.18) | 0.19 | 2.46 (0.88–6.84) | 0.08 |
| Ever-oral route of CYC administration | 3.33 (1.25–8.89) | 0.01 | — | NS |
| CYC dose, by 10-g increments | 1.22 (1.10–1.35) | < 0.001 | 1.24 (1.12–1.38) | < 0.001 |
| Duration of CYC treatment, by 10-month increments | 1.17 (0.94–1.46) | 0.15 | — | NS |
CYC: cyclophosphamide; NS: not significant.