Sensitivity, specificity, and LR for RF, ACPA, and 14-3-3η and combinations without and with inclusion of 14-3-3η.
| Variable | Without 14-3-3η AAb | With 14-3-3η AAb | ||
|---|---|---|---|---|
| Sn/Sp | LR+/LR− | Sn/Sp | LR+/LR− | |
| Early RA vs healthy | ||||
| RF | 0.63/0.87 | 4.96/0.42 | 0.89/0.78 | 4.06/0.15 |
| ACPA | 0.61/1.00 | —* /0.39 | 0.89/0.91 | 9.83/0.12 |
| RF and/or ACPA | 0.72/0.87 | 5.63/0.32 | 0.92/0.78 | 4.22/0.10 |
| 14-3-3η | 0.60/0.85 | 4.1/0.47 | 0.9/0.82 | 4.97/0.12 |
| RF and/or 14-3-3η | 0.75/0.75 | 2.93/0.34 | 0.93/0.71 | 3.20/0.10 |
| ACPA and/or 14-3-3η | 0.72/0.85 | 4.93/0.33 | 0.93/0.82 | 5.11/0.09 |
| RF and/or ACPA and/or 14-3-3η | 0.77/0.75 | 3.02/0.31 | 0.94/0.71 | 3.22/0.09 |
| Early RA vs other arthropathies | ||||
| RF | 0.63/0.85 | 4.35/0.43 | 0.89/0.67 | 2.72/0.17 |
| ACPA | 0.61/0.98 | 25.24/0.4 | 0.89/0.75 | 3.55/0.14 |
| RF and/or ACPA | 0.72/0.84 | 4.44/0.34 | 0.92/0.66 | 2.70/0.12 |
| 14-3-3η | 0.60/0.77 | 2.59/0.52 | 0.9/0.6 | 2.24/0.16 |
| RF and/or 14-3-3η | 0.75/0.70 | 2.5/0.36 | 0.93/0.54 | 2.01/0.13 |
| ACPA and/or 14-3-3η | 0.72/0.76 | 2.96/0.37 | 0.93/0.59 | 2.24/0.12 |
| RF and/or ACPA and/or 14-3-3η | 0.77/0.69 | 2.51/0.33 | 0.94/0.53 | 1.99/0.12 |
| Early RA vs disease controls | ||||
| RF | 0.63/0.84 | 3.83/0.44 | 0.89/0.64 | 2.43/0.18 |
| ACPA | 0.61/0.97 | 23.69/0.40 | 0.89/0.73 | 3.36/0.14 |
| RF and/or ACPA | 0.72/0.82 | 4.09/0.34 | 0.92/0.63 | 2.45/0.13 |
| 14-3-3η | 0.60/0.79 | 2.85/0.51 | 0.90/0.60 | 2.26/0.16 |
| RF and/or 14-3-3η | 0.75/0.70 | 2.49/0.36 | 0.93/0.53 | 1.96/0.13 |
| ACPA and/or 14-3-3η | 0.72/0.78 | 3.23/0.36 | 0.93/0.59 | 2.29/0.12 |
| RF and/or ACPA and/or 14-3-3η | 0.77/0.70 | 2.53/0.33 | 0.94/0.52 | 1.96/0.12 |
| Early RA vs all controls | ||||
| RF | 0.63/0.84 | 4.03/0.44 | 0.89/0.67 | 2.67/0.17 |
| ACPA | 0.61/0.98 | 30.41/0.40 | 0.89/0.77 | 3.94/0.14 |
| RF and/or ACPA | 0.72/0.84 | 4.35/0.34 | 0.92/0.66 | 2.71/0.12 |
| 14-3-3η | 0.60/0.80 | 3.06/0.50 | 0.90/0.65 | 2.58/0.15 |
| RF and/or 14-3-3η | 0.75/0.71 | 2.58/0.36 | 0.93/0.57 | 2.15/0.12 |
| ACPA and/or 14-3-3η | 0.72/0.80 | 3.50/0.36 | 0.93/0.64 | 2.61/0.11 |
| RF and/or ACPA and/or 14-3-3η | 0.77/0.70 | 2.59/0.33 | 0.94/0.56 | 2.15/0.11 |
↵* Could not be calculated because the specificity was 1.0. LR: likelihood ratios; RF: rheumatoid factor; ACPA: anticitrullinated protein antibodies; Sn: sensitivity; Sp: specificity; 14-3-3η: 14-3-3η protein; 14-3-3η AAb: autoantibody; RA: rheumatoid arthritis.