Multinomial logistic regression for univariate and multivariate association of changes of radiographic features from baseline to followup with mild and moderate pain trajectory (marginal pain trajectory is used as reference group). Values are OR (95% CI) unless otherwise specified.
| Variables | Mild Pain vs Marginal Pain | Moderate Pain vs Marginal Pain | ||||
|---|---|---|---|---|---|---|
| OR Univariate | OR Multivariate KL Model B | OR Multivariate OP Model C | OR Univariate | OR Multivariate KL Model B | OR Multivariate OP Model C | |
| KL change | ||||||
| Δ0 | Referent | Referent | Referent | Referent | Referent | |
| Δ1 | 1.3 (0.9–2.0) | 1.4 (0.8–2.0) | 1.2 (0.8–1.9) | 1.1 (0.6–1.9) | 1.1 (0.6–1.9) | |
| Δ2 + Δ3 | 1.7 (0.9–3.5)* | 2.0 (0.9–4.5)* | 2.3 (1.1–4.7)** | 2.9 (1.2–7.1)** | 2.8 (1.0–7.4)** | |
| Osteophyte area change | 1.0 (1.0–1.0) | 1.0 (1.0–1.1) | 1.0 (1.0–1.1) * | 1.0 (1.0–1.1)* | ||
| Min JSW change | 0.9 (0.8–1.1) | 0.9 (0.8–1.1) | ||||
| Hosmer-Lemeshow goodness-of-fit test | 0.322 | 0.327 | 0.322 | 0.327 | ||
| Pseudo Nagelkerke R2 | 0.226 | 0.228 | 0.226 | 0.228 | ||
↵* p value ≤ 0.1, cutoff point in univariate regression.
↵** p value ≤ 0.05. KL change: radiographic change from baseline to followup in index knee. OP area change: OP change from baseline to 5-year followup in index knee. Min JSW change: change in minimal JSW from baseline to followup in index knee. Multivariate KL model B: model corrected for baseline variables (BMI, education, hip pain, worrying, resting, comorbidity, OP size, KL grade) and KL change. Multivariate OP model C: model corrected for baseline variables (BMI, education, hip pain, worrying, resting, comorbidity, OP size) and KL change, change of OP size. KL: Kellgren-Lawrence grading scale; OP: osteophyte; JSW: joint space width; BMI: body mass index.