Unadjusted association of disease severity measures early in pregnancy in women with RA by pregnancy outcomes in the OTIS cohort (n = 440), 2005–2013. Values are median (IQR) unless otherwise specified.
| Enrollment Scores | Overall, n = 440 | Preterm Delivery, n = 66 | Full-term Delivery, n = 373 | p* | SGA n = 39 | Non-SGA, n = 393 | p* | Cesarean Delivery, n = 182 | Vaginal Delivery, n = 255 | p* |
|---|---|---|---|---|---|---|---|---|---|---|
| HAQ-DI, 0–3 | 0.25 (0–0.88) | 0.50 (0.09–1.38) | 0.25 (0–0.75) | 0.008 | 0.63 (0–0.88) | 0.25 (0–0.88) | 0.472 | 0.38 (0.0–1.00) | 0.25 (0–0.70) | 0.030 |
| Pain score, 0–100 | 20 (5–50) | 30 (5–66) | 20 (5–50) | 0.162 | 30 (8–60) | 20 (5–52) | 0.147 | 20 (5–58) | 20 (5–50) | 0.173 |
| Patient global scale, 0–100 | 15 (5–45) | 30 (5–56) | 15 (5–40) | 0.012 | 25 (5–50) | 15 (5–40) | 0.104 | 15 (3–50) | 15 (5–40) | 0.894 |
↵* p using Wilcoxon signed-rank test. RA: rheumatoid arthritis; OTIS: Organization of Teratology Information Specialists Autoimmune Diseases in Pregnancy Project; IQR: interquartile range; SGA: small for gestational age; HAQ-DI: Health Assessment Questionnaire–Disability Index measured in early pregnancy for every unit (0–1) increase in HAQ score.