APPENDIX 1. AE by source. Values are n unless otherwise specified.
| Adverse Events | RA Cases, n = 159 | OA Controls, n = 318 | p | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Prior to Discharge | Office Chart | 6-mo Self-report | Total | Prior to Discharge | Office Chart | 6-mo Self-report | Total | ||
| Major medical AE | 2 | 0 | 5 | 7 | 5 | 3 | 12 | 20 | 0.40 |
| Fracture | 0 | 0 | 1 | 1 | 0 | 1 | 2 | 3 | 0.99 |
| Pneumonia | 1 | 0 | 2 | 3 | 1 | 0 | 1 | 2 | 0.34 |
| DVT | 1 | 0 | 0 | 1 | 3 | 1 | 7 | 11 | 0.07 |
| PE | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 3 | 0.99 |
| Stroke | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0.99 |
| MI | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0.33 |
| Deep surgical site infection | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | — |
| Major bleeding episode | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | — |
| Major surgical AE | 0 | 3 | 1 | 4 | 0 | 26 | 0 | 26 | 0.02 |
| Manipulation | 0 | 2 | 0 | 2 | 0 | 23 | 0 | 23 | 0.01 |
| Revision | 0 | 1 | 0 | 1 | 0 | 3 | 0 | 3 | 0.99 |
| Other reoperation | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0.33 |
| Major AE, excluding death | 2 | 3 | 6 | 11 | 5 | 29 | 12 | 46 | 0.02 |
| Death | 0 | 0 | 2 | 2 | 0 | 0 | 2 | 2 | 0.60 |
| Minor AE | 75 | 12 | 3 | 90 | 129 | 36 | 11 | 176 | 0.79 |
| Minor infection | 4 | 8 | 1 | 13 | 11 | 25 | 6 | 42 | 0.10 |
| Superficial surgical site infection | 2 | 5 | 1 | 8 | 3 | 21 | 6 | 30 | 0.09 |
| Other minor infection | 2 | 3 | 0 | 5 | 8 | 4 | 0 | 12 | 0.73 |
| Transient neuropathy | 2 | 1 | 0 | 3 | 3 | 3 | 0 | 6 | 0.99 |
| Incision drainage | 50 | 0 | 0 | 50 | 87 | 0 | 0 | 87 | 0.35 |
| Erythema | 8 | 0 | 0 | 8 | 17 | 0 | 0 | 17 | 0.88 |
| Ecchymosis | 7 | 0 | 0 | 7 | 4 | 3 | 0 | 7 | 0.25 |
| Atelectasis | 2 | 0 | 0 | 2 | 5 | 0 | 0 | 5 | 0.99 |
| Hematoma | 2 | 0 | 0 | 2 | 2 | 0 | 0 | 2 | 0.60 |
| Minor bleeding episode | 0 | 3 | 2 | 5 | 0 | 5 | 5 | 10 | 0.99 |
Significant data are in bold face. AE: adverse events; RA: rheumatoid arthritis; OA: osteoarthritis; DVT: deep vein thrombosis; PE: pulmonary embolus; MI: myocardial infarction.