Variables | IFX + MTX, n = 9 | NSAID, n = 9 |
---|---|---|
Age at diagnosis, yrs | 11 (7–18) | 11 (7–14) |
Sex, female, n | 6 | 8 |
Race, white, n | 9 | 9 |
Laboratory studies | ||
WBC, 1000/µl | 7.4 (4.6–11.2) | 7.6 (5.6–11.6) |
Hemoglobin, g/dl | 12.5 (10.9–15.1) | 12.3 (10.6–15.1) |
Platelets, 1000/µl | 423 (228–595) | 473 (293–694) |
ESR, mm/h | 15 (4–58) | 17 (0–115) |
CRP, mg/dl | 0.8 (0.5–3.5) | 0.8 (0.2–25.8) |
Bone biopsy obtained, n | 7 | 7 |
Bone culture obtained, n | 5 | 5 |
Bone lesion sites, n | ||
Spine | 4 | 3 |
Pelvis | 6 | 6 |
Clavicle | 2 | 0 |
Long bones | 4 | 8 |
Mandible | 1 | 0 |
Prior medications, n | ||
None | 2 | 2 |
Antibiotics | 3 | 7 |
NSAID | 6 | 0 |
Prednisone | 2 | 0 |
Methotrexate | 1 | 0 |
Bisphosphonate | 1 | 0 |
Other TNF-α inhibitor | 1 | 0 |
CNO: chronic nonbacterial osteomyelitis; IFX: infliximab; MTX: methotrexate; NSAID: nonsteroidal antiinflammatory drugs; WBC: white blood cells; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; TNF: tumor necrosis factor.