Patients’ characteristics for the total study sample (first column) as well as subgroups of patients according to their level of the cMMI. Values are mean (SD) or % unless otherwise specified.
| Characteristics | Total Study Sample, n = 3920 | Subgroups of Patients according to Multimorbidity Index, cMMI | |||||
|---|---|---|---|---|---|---|---|
| RA Only, n = 1357 (34.6%) | cMMI = 2, n = 1047 (26.7%) | cMMI = 3, n = 725 (18.5%) | cMMI = 4, n = 430 (11.0%) | cMMI ≥ 5, n = 361 (9.2%) | p | ||
| Age, yrs | 56.3 (13.0) | 51.0 (13.3) | 58.4 (12) | 58.8 (12.9) | 59.1 (11.2) | 61.3 (10.9) | < 0.01* |
| Female | 81.7 | 82.2 | 81.9 | 81.5 | 79.8 | 81.7 | 0.86^ |
| Disease duration, yrs | 9.6 (8.7) | 8.4 (7.5) | 10.2 (9.1) | 10.4 (9.3) | 10.1 (8.9) | 10.2 (9.5) | < 0.01* |
| Seropositive, RF, and/or ACPA | 82.2 | 84.6 | 81.7 | 80.1 | 79.9 | 81.5 | 0.06^ |
| SJC28 | 2.7 (4.0) | 3.0 (4.1) | 2.5 (3.6) | 2.7 (3.9) | 2.8 (4.2) | 2.6 (4.1) | 0.23* |
| TJC28 | 4.0 (5.4) | 3.8 (5.4) | 3.6 (4.8) | 4.3 (5.5) | 4.7 (6.0) | 4.7 (5.7) | < 0.01* |
| ESR | 26.8 (22.7) | 26.1 (22.5) | 25.1 (22.5) | 27.8 (22) | 28.3 (23.2) | 30.8 (24.3) | < 0.01* |
| DAS28 | 3.7 (1.6) | 3.7 (1.6) | 3.6 (1.5) | 3.8 (1.5) | 3.9 (1.6) | 4.0 (1.5) | < 0.01* |
| CDAI | 13.7 (11.6) | 13.5 (11.9) | 12.8 (10.7) | 13.9 (11.6) | 14.9 (13.0) | 15.3 (11.7) | < 0.01* |
| HAQ | 1.04 (0.7) | 0.93 (0.6) | 0.98 (0.6) | 1.11 (0.7) | 1.16 (0.7) | 1.27 (0.7) | < 0.01* |
| mHAQ | 0.51 (0.6) | 0.42 (0.5) | 0.46 (0.5) | 0.57 (0.6) | 0.61 (0.6) | 0.7 (0.6) | < 0.01* |
| PtGA | 3.9 (2.6) | 3.7 (2.5) | 3.7 (2.5) | 4.0 (2.6) | 4.1 (2.7) | 4.3 (2.6) | < 0.01* |
| EGA | 3.0 (2.2) | 2.9 (2.2) | 2.8 (2.1) | 2.9 (2.3) | 3.2 (2.4) | 3.3 (2.2) | < 0.01* |
| EQ-5D | 0.68 (0.3) | 0.72 (0.3) | 0.70 (0.2) | 0.65 (0.3) | 0.63 (0.3) | 0.60 (0.3) | < 0.01* |
| No. DMARD taken overall | 2.8 (1.7) | 2.6 (1.6) | 2.8 (1.7) | 2.7 (1.8) | 2.9 (1.8) | 2.9 (1.9) | 0.014* |
| Smoking current | 13.2 | 12.1 | 13.5 | 13.2 | 14.3 | 14.9 | 0.58^ |
| Married | 69.7 | 71.5 | 69.6 | 69.8 | 68.0 | 64.7 | 0.15^ |
| Education highest level university | 25.0 | 28.1 | 24.2 | 21.1 | 20.7 | 23.6 | < 0.01^ |
| Erosive disease | 53.7 | 52.3 | 54.9 | 55.6 | 52.2 | 54.2% | 0.55^ |
↵* Analyses of variance testing for linear trend.
↵^ Chi-square test for trend. cMMI: counted multimorbidity index; RA: rheumatoid arthritis; RF: rheumatoid factor; ACPA: anticitrullinated protein antibodies; SJC28: swollen joint count at 28 joints; TJC28: tender joint count at 28 joints; ESR: erythrocyte sedimentation rate; DAS28: Disease Activity Score at 28 joints; CDAI: Clinical Disease Activity Index; HAQ: Health Assessment Questionnaire; mHAQ: modified HAQ; PtGA: patient’s global assessment; EGA: evaluator global assessment; DMARD: disease-modifying antirheumatic drugs.