Genetic variants attaining a significant association with radiological progression.
| SNP (Gene) or HLA-DRB1 Allele or HLA Amino Acid | All RA, n = 524 | ACPA+, n = 350 | ACPA–, n = 149 | |||
|---|---|---|---|---|---|---|
| β (95% CI) | p | β (95% CI) | p | β (95% CI) | p | |
| rs660895 (HLA-DRB1*04:01 tag) | 1.07 (1.03–1.12) | 0.0003 | 1.07 (1.02–1.13) | 0.0037 | 1.03 (0.96–1.11) | 0.4571 |
| HLA-DRB1*04:01 | 1.10 (1.05–1.15) | 0.0002 | 1.08 (1.02–1.14) | 0.0105 | 1.04 (0.94–1.16) | 0.4344 |
| Histidine at position 13 in HLA-DRβ1 | 1.07 (1.03–1.12) | 0.0005 | 1.07 (1.02–1.13) | 0.0060 | 1.02 (0.95–1.10) | 0.5590 |
| Valine at position 11 in HLA-DRβ1 | 1.07 (1.03–1.11) | 0.0012 | 1.07 (1.01–1.12) | 0.0111 | 1.02 (0.95–1.10) | 0.6130 |
p values from the linear-mixed effects model genotype*time interaction term. ACPA status missing in 25 patients. Bonferroni-corrected p value thresholds for SNP, HLA-DRB1 alleles, and HLA amino acid polymorphisms in all RA are 0.0007, 0.0033, and 0.0019, respectively. Bonferroni-corrected p value threshold for the 4 markers tested in ACPA-positive and ACPA-negative RA is 0.0125. SNP: single-nucleotide polymorphism; RA: rheumatoid arthritis; ACPA: anticitrullinated protein antibodies.