Association of SLE disease criteria and anti-dsDNA assessed by 4 different assays. The analysis (Fisher’s exact test) is not adjusted for multiple comparisons.
| Cumulative ACR-82 Criteria* (% fulfilling the criterion) | FIDIS | EliA | CLIFT | EUROLINE | ||||
|---|---|---|---|---|---|---|---|---|
| p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | |
| 1. Malar rash (45%) | 0.325 | 1.41 (0.74–2.69) | 0.753 | 1.12 (0.60–2.08) | 0.726 | 0.84 (0.42–1.70) | 0.870 | 1.08 (0.57–2.05) |
| 2. Discoid rash (17%) | 0.084 | 0.40 (0.14–1.10) | 0.302 | 0.60 (0.25–1.43) | 0.356 | 0.55 (0.20–1.54) | 0.391 | 0.62 (0.25–1.54) |
| 3. Photosensitivity (56%) | 0.047 | 0.49 (0.26–0.95) | 0.752 | 0.86 (0.46–1.60) | 0.003 | 0.33 (0.16–0.67) | 0.104 | 0.58 (0.31–1.11) |
| 4. Oral ulcers (10%) | 0.587 | 1.32 (0.46–3.79) | 0.035 | 3.00 (1.08–8.31) | 0.249 | 1.83 (0.63–5.28) | 0.405 | 1.70 (0.61–4.73) |
| 5. Arthritis (78%) | 0.692 | 0.81 (0.38–1.73) | 0.447 | 0.71 (0.34–1.47) | 0.674 | 1.30 (0.55–3.10) | 1.0 | 0.97 (0.45–2.11) |
| 6. Serositis (38%) | 0.315 | 1.42 (0.73–2.72) | 0.746 | 0.87 (0.46–1.65) | 0.588 | 1.26 (0.63–2.55) | 0.737 | 0.86 (0.44–1.67) |
| 7. Renal disorder (21%) | 0.01 | 2.70 (1.29–5.68) | 0.004 | 2.98 (1.43–6.23) | 0.054 | 2.23 (1.03–4.85) | 0.171 | 1.69 (0.80–3.57) |
| 8. Neurologic disorder (6%) | 1.0 | 0.98 (0.25–3.98) | 0.321 | 1.95 (0.54–7.00) | 1.0 | 0.77 (0.15–3.79) | 0.174 | 0.41 (0.11–1.49) |
| 9. Hematologic disorder (57%) | 0.013 | 2.42 (1.21–4.83) | 0.525 | 1.28 (0.69–2.41) | 0.480 | 1.35 (0.67–2.73) | 0.621 | 1.23 (0.65–2.35) |
| 1, 2, or 3. Skin (75%) | 0.086 | 0.51 (0.25–1.04) | 1.0 | 1.04 (0.51–2.14) | 0.001 | 0.29 (0.14–0.60) | 0.091 | 0.53 (0.26–1.08) |
Significant data are in bold face.
↵* Immunologic disorder (ACR criterion 10, 49% of patients) and antinuclear antibodies (ACR criterion 11, 98% of patients) are not reported because all anti-dsDNA–positive patients by CLIFT fulfill these criteria. Manufacturer’s cutoff (FIDIS, EliA, and EUROLINE) or laboratory reference cutoff (CLIFT) for positivity were used. SLE: systemic lupus erythematosus; ACR-82: American College of Rheumatology 1982 criteria; FIDIS: bead-based multiplex assay; EliA: fluoroenzyme-immunoassay; CLIFT: Crithidia luciliae immunofluorescence test; EUROLINE: line blot.