Laboratory values of lipid and liver function.
| Change Observed | No. Patients Treated with TCZ-SC-mono, total = 346 |
|---|---|
| Shift in total cholesterol from baseline < 200 mg/dl to last observed value over Week 108 | |
| N | 266 |
| < 200 | 132 |
| ≥ 200 to < 240 | 102 |
| ≥ 240 | 32 |
| Shift in HDL cholesterol from baseline < 40 mg/dl to last observed value over Week 108 | |
| N | 43 |
| < 40 | 12 |
| ≥ 40 to < 60 | 26 |
| ≥ 60 | 5 |
| Shift in LDL cholesterol from baseline < 100 mg/dl to last observed value over Week 108 | |
| N | 166 |
| < 100 | 74 |
| ≥ 100 to < 130 | 75 |
| ≥ 130 to < 160 | 13 |
| ≥ 160 to < 190 | 3 |
| ≥ 190 | 1 |
| Shift in ALT from normal at baseline to worst CTC grade | |
| N | 329 |
| Normal | 223 |
| Grade 1 | 91 |
| Grade 2 | 12 |
| Grade 3 | 3 |
| Grade 4 | 0 |
| Shift in AST from normal at baseline to worst CTC grade | |
| N | 338 |
| Normal | 257 |
| Grade 1 | 73 |
| Grade 2 | 7 |
| Grade 3 | 1 |
| Grade 4 | 0 |
| Shift in total bilirubin from normal at baseline to worst CTC grade | |
| N | 345 |
| Normal | 277 |
| Grade 1 | 55 |
| Grade 2 | 13 |
| Grade 3 | 0 |
| Grade 4 | 0 |
| Shift in neutrophils from normal at baseline to worst CTC grade | |
| N | 342 |
| Normal | 205 |
| Grade 1 | 51 |
| Grade 2 | 67 |
| Grade 3 | 18 |
| Grade 4 | 1 |
| Shift in platelets from normal at baseline to worst CTC grade | |
| N | 341 |
| Normal | 311 |
| Grade 1 | 29 |
| Grade 2 | 1 |
| Grade 3 | 0 |
| Grade 4 | 0 |
ALT: alanine aminotransferase; AST: aspartate aminotransferase; CTC: common terminology criteria; HDL: high-density lipoprotein; IV: intravenous; LDL: low-density lipoprotein; SC: subcutaneous; TCZ: tocilizumab; TCZ-SC-mono: subcutaneous TCZ montherapy.